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The role of glucocorticoid in mitochondria-dependent resistance to anticancer therapy

Research Project

Project/Area Number 24501353
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical oncology
Research InstitutionOsaka City University

Principal Investigator

KASAHARA EMIKO  大阪市立大学, 医学(系)研究科(研究院), 講師 (30468269)

Co-Investigator(Kenkyū-buntansha) KUBO Shuji  兵庫医科大学, 医学部, 准教授 (10441320)
Co-Investigator(Renkei-kenkyūsha) SEKIYAMA Atsuo  大阪大学, 薬学研究科, 教授 (30403702)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsグルココルチコイド / ミトコンドリア / 抗がん剤 / ストレス / 中皮腫 / シスプラチン / 薬剤耐性 / 抗がん剤耐性
Outline of Final Research Achievements

Those intense stress by a side effect of chemotherapy as well as the pain with the cancer also influence the therapeutic effects of the anticancer agents.
However, little is known about the mechanisms of these untoward actions. In this study, we investigated the influence of glucocorticoids, which is a stress-related hormone on anticancer drug actions. Our results suggest that stress-induced glucocorticoids attenuate the action of anticancer drug through the alteration of mitochondrial function.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (7 results) (of which Invited: 3 results)

  • [Journal Article] Stress-Induced Glucocorticoid Release Upregulates Uncoupling Protein-2 Expression and Enhances Resistance to Endotoxin-Induced Lethality2015

    • Author(s)
      Kasahara E, Sekiyama A, Hori M, Kuratsune D, Fujisawa N, Chida D, Hiramoto H, Li J, Okamura H, Inoue M, Kitagawa S.
    • Journal Title

      Neuroimmunomodulation

      Volume: ー Issue: 5 Pages: 279-292

    • DOI

      10.1159/000368802

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cross-talk between HPA-axis-increased glucocorticoids and mitochondrial stress determines immune responses and clinical manifestations of patients with sepsis.2015

    • Author(s)
      Kasahara E, Inoue M.
    • Journal Title

      Redox Rep.

      Volume: 20 Issue: 1 Pages: 1-10

    • DOI

      10.1179/1351000214y.0000000107

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.2015

    • Author(s)
      Matsushita K, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Fukuyo M, Kaneda A, Iwama A, Nomura F.
    • Journal Title

      Oncotarget

      Volume: 10 Pages: 5102-17

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate into Neural and Vascular Lineage Cells.2015

    • Author(s)
      Nakagomi T, Kubo S, Nakano-Doi A, Sakuma R, Lu S, Narita A, Kawahara M, Taguchi A, Matsuyama T.
    • Journal Title

      Stem Cells.

      Volume: ー Issue: 6 Pages: 1962-1974

    • DOI

      10.1002/stem.1977

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/ cyclinE and Ku86/ XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway.2014

    • Author(s)
      Rahmutulla B, Matsushita K, Satoh M, Seimiya M, Tsuchida S, Kubo S, Shimada H, Ohtsuka M, Miyazaki M, Nomura F.
    • Journal Title

      Oncotarget

      Volume: 15 Pages: 2404-17

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncolytic virotherapy for osteosarcoma using midkine promoter-regulated adenoviruses.2014

    • Author(s)
      Takagi-Kimura M, Yamano T, Tagawa M, Kubo S
    • Journal Title

      Cancer Gene Ther.

      Volume: 21 Issue: 3 Pages: 126-32

    • DOI

      10.1038/cgt.2014.7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of stress-induced glucocorticoids in innate immune response2014

    • Author(s)
      笠原恵美子、関山敦生、堀美香、井上正康
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparative evaluation of suicide gene therapy using retroviral peplicating vectors in an experimental model of human malignant mesothelioma.2014

    • Author(s)
      Kubo Shuji, Kasahara Noriyuki.
    • Organizer
      iMig 2014
    • Place of Presentation
      Cape town (South Africa)
    • Year and Date
      2014-10-21 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 自然免疫応答におけるHPA軸の役割とミトコンドリアの関与2013

    • Author(s)
      笠原恵美子、関山敦生、堀美香、千田大、井上正康、北川誠一
    • Organizer
      第66回 臨床酸化ストレス学会
    • Place of Presentation
      ウインク愛知(名古屋市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Role of the HPA-axis and mitochondria in LPS-induced septic shock2013

    • Author(s)
      E Kasahara, A. Sekiyama, M. Hori, D. Chida, H. Okamura, M Inoue, S Kitagawa.
    • Organizer
      6th Joint Meeting of the Societies for Free Radical Research
    • Place of Presentation
      Mercure Sydney Hotel (SYDNEY Australia)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ストレス応答とミトコンドリア代謝2012

    • Author(s)
      笠原恵美子
    • Organizer
      第3回 生殖ミトコンドリア研究会
    • Place of Presentation
      IVFなんばクリニック マーメードホール(大阪市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ミトコンドリアと癌医療2012

    • Author(s)
      笠原恵美子
    • Organizer
      第29回 臨床フリーラジカル会議
    • Place of Presentation
      けぶり河 多目的ホール(京都府亀岡市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ストレス負荷による自然免疫抑制機構とミトコンドリアの関与2012

    • Author(s)
      笠原恵美子、関山敦生、堀美香、千田大、井上正康、北川誠一
    • Organizer
      第85回 日本生化学会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡市)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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