| Project/Area Number |
24501360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | National Cancer Center Japan (2013-2014)
Kinki University (2012) |
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Principal Investigator |
OKAMOTO Wataru 独立行政法人国立がん研究センター, 早期・探索臨床研究センター, 医員 (30441075)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Kazuhiko 近畿大学, 医学部, 教授 (40298964)
NISHIO Kazuto 近畿大学, 医学部, 教授 (10208134)
OKAMOTO Isamu 九州大学, 大学病院, 学術研究員 (10411597)
ARAO Tokuzo 近畿大学, 医学部, 講師 (20441074)
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| Research Collaborator |
KAWAKAMI Hisato
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | MET遺伝子増幅 / 胃癌 / 分子標的薬 / Gastric Cancer / MET / Resistance / 分子標的治療 |
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| Outline of Final Research Achievements |
We previously showed that induction of apoptosis underlies the antiproliferative effect of MET tyrosine kinase inhibitors (MET-TKIs) in gastric cancer cells with MET amplification. In the present study, we showed the molecular mechanism underlying its MET-TKIs-induced apoptosis. We also determined the prevalence, clinical features and prognosis of gastric cancer with MET amplification. We further established the MET-TKIs-resistant gastric cancer cell lines, which is important to reveal the MET-TKIs-resistant mechanisms.
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