| Project/Area Number |
24501362
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | Shizuoka Cancer Center Research Institute |
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Principal Investigator |
ASHIZAWA Tadashi 静岡県立静岡がんセンター(研究所), その他部局等, その他 (10443441)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Yasuto 静岡県立静岡がんセンター研究所 (70222552)
ANDO Takayuki 静岡県環境衛生科学研究所 (40402226)
小郷 尚久 静岡県立大学, 薬学研究科(研究院), 講師 (20501307)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | がん幹細胞治療薬 / 国際情報交換 |
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| Outline of Final Research Achievements |
Despite of an intensive therapy, the prognosis of malignant gliomas is still poor, and average overall survival is only about a year. Therefore, the development of new drugs against gliomas has been required. In recent years, the novel therapeutic regimens against cancer stem cells have been investigated. In the current study, We established a small-molecule compound library screening system consisting of in silico study and in vitro proliferation assay using glioma patients-derived stem cell lines in a collaboration with Shizuoka Institute of Environment and Hygiene. So far we found that five promising compounds which have potent inhibitory activity on stem cell proliferation, and even a few compounds showed anti-stem cell tumor activity in vivo. In the future, through preclinical safety and drug delivery study of identified compounds, we are planning to pursue the possibility of a new therapeutic agent against glioma stem cell.
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