| Project/Area Number |
24501364
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cancer epidemiology and prevention
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| Research Institution | Kumamoto University |
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Principal Investigator |
KATOH Takahiko 熊本大学, 大学院生命科学研究部, 教授 (70169506)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANO Yuko 昭和大学, 医学部, 准教授 (30167580)
TAKAHASHI Hiroyuki 慈恵会医科大学, 医学部, 准教授 (00246414)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 前立腺がん / 分子疫学 / 栄養学 / 予防医学 / 遺伝子多型 / 食物摂取頻度調査 / ライフスタイル / 遺伝子検査 / 予防医療 |
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| Outline of Final Research Achievements |
We conducted a comprehensive epidemiological analysis of genetic and environmental factors to clarify the risk factors for prostate cancer (PCa) in Japanese nationals.
Result: 1) There are no significant increased risks of PCa on quantified nutrients at present. 2) Estrogen receptor 2 (ESR2) rs4986938 AG and AG + AA genotypes were associated with significantly decreased risk of PCa (AG: OR= 0.68, 95% CI, 0.47-0.97, P < 0.05 and AG + AA: OR= 0.67, 95% CI, 0.47-0.94, P< 0.05). When patients were grouped according to smoking status, the ESR2 rs1256049 AA genotype (OR= 0.48, 95% CI, 0.25-0.95, P< 0.05) and ESR2 rs4986938 AG + AA genotype (OR= 0.64, 95% CI, 0.41-1.00, P< 0.05) showed significantly decreased PCa risk in the ever-smoker group.
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