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Nutrition and molecular genetic epidemiology analysis of prostate cancer

Research Project

Project/Area Number 24501364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cancer epidemiology and prevention
Research InstitutionKumamoto University

Principal Investigator

KATOH Takahiko  熊本大学, 大学院生命科学研究部, 教授 (70169506)

Co-Investigator(Renkei-kenkyūsha) YAMANO Yuko  昭和大学, 医学部, 准教授 (30167580)
TAKAHASHI Hiroyuki  慈恵会医科大学, 医学部, 准教授 (00246414)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords前立腺がん / 分子疫学 / 栄養学 / 予防医学 / 遺伝子多型 / 食物摂取頻度調査 / ライフスタイル / 遺伝子検査 / 予防医療
Outline of Final Research Achievements

We conducted a comprehensive epidemiological analysis of genetic and environmental factors to clarify the risk factors for prostate cancer (PCa) in Japanese nationals.
Result: 1) There are no significant increased risks of PCa on quantified nutrients at present. 2) Estrogen receptor 2 (ESR2) rs4986938 AG and AG + AA genotypes were associated with significantly decreased risk of PCa (AG: OR= 0.68, 95% CI, 0.47-0.97, P < 0.05 and AG + AA: OR= 0.67, 95% CI, 0.47-0.94, P< 0.05). When patients were grouped according to smoking status, the ESR2 rs1256049 AA genotype (OR= 0.48, 95% CI, 0.25-0.95, P< 0.05) and ESR2 rs4986938 AG + AA genotype (OR= 0.64, 95% CI, 0.41-1.00, P< 0.05) showed significantly decreased PCa risk in the ever-smoker group.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] 産業保健と遺伝子情報2015

    • Author(s)
      加藤貴彦、中下千尋、藤原悠基
    • Journal Title

      産業医学ジャーナル

      Volume: 38 Pages: 76-82

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population.2013

    • Author(s)
      Cui X, Lu X, Hiura M, Omori H, Miyazaki W, Katoh T.
    • Journal Title

      Environ Health Prev Med.

      Volume: 18 Issue: 2 Pages: 136-142

    • DOI

      10.1007/s12199-012-0302-x

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese2012

    • Author(s)
      赤松秀輔, 他
    • Journal Title

      Nature Genetics

      Volume: 44 Issue: 4 Pages: 426-429

    • DOI

      10.1038/ng.1104

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] シンポジウム:産業保健への新たなバイオマーカーの探索 遺伝的感受性バイオマーカーを利用した産業保健活動2014

    • Author(s)
      加藤貴彦
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遺伝子情報から有害化学物質使用者の健康を考える2013

    • Author(s)
      加藤貴彦
    • Organizer
      第86回日本産業衛生学会 シンポジウム2
    • Place of Presentation
      愛媛県松山市ひめぎんホール
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 薬物代謝酵素cytochrome P450 (CYP) 1A2、N-acetylransferase(NAT)2、sulfotransferase (SULT) 1A1、UDP-glucuronosyltransferase (UGT) 2B7遺伝子多型と膀胱がん感受性2012

    • Author(s)
      崔笑怡、盧渓、日浦瑞枝、小田政子、宮崎航、大森久光、加藤 貴彦
    • Organizer
      第71回日本公衆衛生学会
    • Place of Presentation
      山口県 山口市 サンルート国際ホテル山口
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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