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Exposure assessment of heterocyclic aromatic amines among Japanese and Japanese Brazilians.

Research Project

Project/Area Number 24501366
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cancer epidemiology and prevention
Research InstitutionNational Cancer Center Japan

Principal Investigator

IWASAKI Motoki  独立行政法人国立がん研究センター, がん予防・検診研究センター, 部長 (60392338)

Co-Investigator(Renkei-kenkyūsha) TSUGANE Shoichiro  独立行政法人国立がん研究センター, がん予防・検診研究センター, センター長 (40179982)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords曝露評価 / 生体試料 / 食物摂取頻度調査票 / 妥当性研究 / 日系人
Outline of Final Research Achievements

We conducted validation studies using PhIP level in hair to establish the method of exposure assessment for heterocyclic aromatic amines (HAAs) among Japanese and Japanese Brazilians. The validation study in Japanese suggested that our food frequency questionnaire (FFQ) for Japanese is reasonably valid for the assessment of HAA intake. On the other hand, the validation study in Japanese Brazilians suggested that the assessment of HAA intake by FFQ for Japanese Brazilians should be revised. When PhIP level in hair was used as exposure indicator, it was higher in Japanese Brazilians than Japanese.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (1 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Dietary heterocyclic amine intake, NAT2 genetic polymorphism, and colorectal adenoma risk: the colorectal adenoma study in Tokyo.2015

    • Author(s)
      Budhathoki S, Iwasaki M, Yamaji T, Sasazuki S, Takachi R, Sakamoto H, Yoshida T, Tsugane S.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev.

      Volume: 24 Issue: 3 Pages: 613-20

    • DOI

      10.1158/1055-9965.epi-14-1051

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Validity of a self-administered food frequency questionnaire in the estimation of heterocyclic aromatic amines.2014

    • Author(s)
      Iwasaki M, Mukai T, Takachi R, Ishihara J, Totsuka Y, Tsugane S.
    • Journal Title

      Cancer Causes Control.

      Volume: 25 Issue: 8 Pages: 1015-28

    • DOI

      10.1007/s10552-014-0401-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Validation of a quantitative FFQ for a study of diet and risk of colorectal adenoma among Japanese Brazilians.2012

    • Author(s)
      Pakseresht M, Miyajima NT, Shelton A, Iwasaki M, Tsugane S, Le Marchand L, Sharma S.
    • Journal Title

      Public Health Nutr.

      Volume: Aug 14 Pages: 901-9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] シンポジウム「がん疫学研究:国民全体および個別化の確かながん予防実現に向けて」 ”移民研究から推定されるがん予防効果”2013

    • Author(s)
      岩崎基、津金昌一郎
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 予防研究グループホームページ

    • URL

      http://epi.ncc.go.jp/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 予防研究グループホームページ

    • URL

      http://epi.ncc.go.jp/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 予防研究部ホームページ

    • URL

      http://epi.ncc.go.jp/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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