| Budget Amount *help |
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Outline of Final Research Achievements |
Nijmegen breakage syndrome (NBS) is a member of chromosome instability syndromes. The responsible gene product of NBS, NBS1, quickly responds to DNA double strand breaks (DSBs) induced by ionizing radiation, and functions to prevent chromosome instability, carcinogenesis and cell death. However, molecular mechanisms of these functions remain largely unknown. In this study, we proved that NBS1 functions in non-homologous end joining (NHEJ), which is one of the major pathways of DSB repair. In addition, we also revealed that the specific region of NBS1 has a specialized function in NHEJ.
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