| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Reactive oxygen species (ROS) are generated continually in living cells during normal cellular metabolism and also generated by exogenous sources such as ionizing radiation and various chemical oxidants. ROS are highly reactive and damage DNA, causing strand breaks and many types of damaged bases. If such damages are not eliminated or repaired, they lead to cellular dysfunction, cell death, mutations, cancer and aging. Cells protect themselves from ROS by preventing oxidative cellular damage, through repair of oxidative damages. In this study, we identified several DNA repair enzymes from C. elegans, and clarified their involvement in aging, embryo development and body growth. We also analysed the role of DNA repair enzymes against biological consequences of ionising radiation.
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