| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Ku (the heterodimer of Ku70 and Ku80) plays a pivotal role in the DNA double-strand break (DSB) repair pathway (non-homologous end-joining (NHEJ). It has reported that two isoforms of Ku80 encoded by the same genes are expressed and function in primate cells, but not in rodent cells. In this study, our data suggested the possibility that nuclear localization signal of one isoform is localized not only in the C-terminal region, but also in the N-terminal region. In addition, we generated a transgenic mouse that were introduced GFP-KARP-1(1-88). These information and the mouse generated might be useful for study of KARP-1(1-88) functions and the DSB repair pathway.
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