Establishment of a protocol to examine the effects of endocrine disrupting chemicals on anuran metamorphosis.
| Project/Area Number |
24510083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUZUKI Ken-ichi 広島大学, 理学(系)研究科(研究院), 特任講師 (90363043)
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| Research Collaborator |
KASHIWAGI Akihiko 広島大学, 大学院理学研究科, 特任教授 (50106796)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 甲状腺ホルモン / 変態 / 無尾両生類 / ツメガエル / 甲状腺ホルモン受容体 / トランスジェニック / 内分泌撹乱 / 甲状腺軸 / 副腎軸 / 甲状腺かく乱物質 / グルココルチコイド / 脳 |
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| Outline of Final Research Achievements |
The purpose of this research is to establish a new protocol to examine the effects of endocrine disrupting chemicals on anuran metamorphosis. Focusing on the molecular mechanism by which endocrine disruptors disturb metamorphosis, we tried to develop reporter transgenic lines and to analyze metamorphosis-related genes in Xenopus laevis and Xenopus tropicalis.
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Report
(4 results)
Research Products
(16 results)
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[Presentation] Effects of amiodarone, thyroid hormone-like chemicals on amphibian metamorphosis
Author(s)
佐能正剛, 柏木啓子, 花田秀樹, 松原加奈, 川畑公平, 中村直樹, 鈴木賢一,山本 卓, 新海 正, 藤本成明, 杉原数美, 北村繁幸, 柏木昭彦, 太田 茂
Organizer
第15回環境ホルモン学会研究発表会
Place of Presentation
東京大学本郷キャンパス
Related Report
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