| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To obtain non-invasive and real-time information on release of drugs for biodegradable polymer nanoparticles, the aim of this study is development of method to visualize the polymer nanoparticles administrated in a living body and to follow their changes by Overhauser enhanced magnetic resonance imaging (OMRI). We obtained OMRI images of polymer nanoparticles labeled with nitroxyl radicals, as a phantom sample or orally administrated sample in stomach of a mouse. Image intensities of the OMRI images for the phantom sample increased for 12 hours after preparation. The changes in image intensities of the OMRI with times for the orally administrated sample were different from those for orally administrated free nitroxyl radicals.
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