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Development of scanning atom probe technique for small molecular systems and its application for biomolecules

Research Project

Project/Area Number 24510157
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionKanazawa Institute of Technology

Principal Investigator

TANIGUCHI Masahiro  金沢工業大学, バイオ・化学部, 教授 (30250418)

Co-Investigator(Kenkyū-buntansha) YAMAGISHI Akihiko  東邦大学, 理学部, 訪問教授 (70001865)
Co-Investigator(Renkei-kenkyūsha) NISHIKAWA Osamu  金沢工業大学, 産学連携室, 教授 (10108235)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords走査型アトムプローブ / 質量分析 / 生体分子 / アミノ酸 / 電界蒸発
Outline of Final Research Achievements

Scanning atom probe was applied for molecular systems which consist not of covalent bonded materials but of free molecules. Using single walled carbon nanotube as solid supporter which produced a strong field on their protruding apexes, mass spectra of 16 of 20 common amino acids were obtained. The results suggested that the migration of molecules to the apex region of the support is required for stable analysis. The cooling down the temperature was not favored for the analysis of molecules examined here. A new dual trigger system was developed to apply voltage pulse and laser pulse alternately to an identical sample. The dual trigger analysis showed that the mass spectrum obtained by voltage pulse and laser pulse were different and the selective evaporation would be possible by controlling the sequence of triggers

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (29 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (17 results) (of which Int'l Joint Research: 2 results) Book (3 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Scanning Atom Probe Analysis Alternately Triggered by Voltage and Laser Pulse2016

    • Author(s)
      Masahiro Taniguchi and Osamu Nishikawa
    • Journal Title

      e-Journal of Surface Science and Nanotechnology

      Volume: 14 Pages: 69-72

    • NAID

      130005132816

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Atomic level analysis of dipeptide biomolecules by a scanning atom probe2016

    • Author(s)
      Masahiro Taniguchi and Osamu Nishikawa
    • Journal Title

      Journal of Vacuum Science and Technology B

      Volume: 34 Issue: 3

    • DOI

      10.1116/1.4941426

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Atomic level analysis of carbon fibers by the scanning atom probe2014

    • Author(s)
      Osamu Nishikawa and Masahiro Taniguchi
    • Journal Title

      Surface and Interface Analysis

      Volume: 46 Issue: 12-13 Pages: 1231-1235

    • DOI

      10.1002/sia.5695

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chirality Effects on Core-periphery Connection in a Star-burst Type Tetranuclear Ru(III) Complex : Application of Vibrational Circular Dichroism Spectroscopy2012

    • Author(s)
      Hisako Sato, Fumi Sato, Masahiro Taniguchi, Akihiko Yamagishi
    • Journal Title

      Dalton Transactions

      Volume: 41 Issue: 6 Pages: 1709-1712

    • DOI

      10.1039/c1dt11510c

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 走査型アトムプローブによるアミノ酸の原子レベルでの解析 :グルタミンとグルタミン酸2016

    • Author(s)
      西川 治、谷口 昌宏
    • Organizer
      応用物理学会春季学術講演会
    • Place of Presentation
      東工大大岡山キャンパス
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 27p-P-14 Scanning Atom Probe Study of Molecular System2015

    • Author(s)
      Masahiro Taniguchi and O. Nishikawa
    • Organizer
      10th International Symposium on Atomic Level Characterizations for New Materials and Devices '15
    • Place of Presentation
      くにびきメッセ(島根県松江市)
    • Year and Date
      2015-10-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 走査型アトムプローブによるアミノ酸の原子レベルでの解析 :バリンとプロリン2015

    • Author(s)
      西川 治、谷口 昌宏
    • Organizer
      応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] O2-16 Analysis of amino acids by the scanning atom probe2015

    • Author(s)
      Masahiro Taniguchi
    • Organizer
      The Scientific International Symposium on SIMS and Related Techniques Based on Ion-Solid Interactions
    • Place of Presentation
      成蹊大学
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アトムプローブにおける電界蒸発トリガー方法2015

    • Author(s)
      谷口昌宏、西川治
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学理工学部船橋キャンパス (千葉県・船橋市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 走査型アトムプローブによるペプチドの原子レベルでの定性・定量解析2015

    • Author(s)
      西川 治、谷口 昌宏
    • Organizer
      第62回応用物理学会春季学術講演会
    • Place of Presentation
      東海大学 湘南キャンパス (神奈川県・平塚市)
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] アトムプローブにおける電界蒸発トリガー方法の比較2014

    • Author(s)
      谷口昌宏
    • Organizer
      日本表面科学会
    • Place of Presentation
      島根県立 産業交流会館 (島根県・松江市)
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 走査型アトムプローブによる炭素繊維の原子レベルでの解析(3) 定量的組成分析2014

    • Author(s)
      西川 治、谷口 昌宏
    • Organizer
      第75回応用物理学会秋季学術講演会
    • Place of Presentation
      北海道大学 (北海道・札幌市)
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Atomic Level Analysis of Etched Carbon Fibers by the Scanning Atom Probe2014

    • Author(s)
      M. Taniguchi
    • Organizer
      SISS-16 (The Scientific International Symposium on SIMS and Related Techniques Based on Ion-Solid Interactions
    • Place of Presentation
      Hokkaido University (北海道・札幌市)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Atom probe analysis of electroconductive polymers

    • Author(s)
      M. Taniugchi
    • Organizer
      SISS-15 in 2013 (The International symposium on SIMS and Related Techniques Base on Ion-Solid Interactions at Seikei University)
    • Place of Presentation
      成蹊大学 (東京都 武蔵野市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 走査型アトムプローブによる有機高分子膜(ウルシ膜)の分析2

    • Author(s)
      谷口昌宏、西川治
    • Organizer
      第33回表面科学学術講演会
    • Place of Presentation
      つくば国際会議場 (茨城県つくば市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Atomic Level Analysis of Carbon Fibers by the Scanning Atom Probe

    • Author(s)
      O. Nishikawa and M. Taniguchi
    • Organizer
      9th International symposium on Atomic Lebel Characterizations for New Materials and Devices '13 (ALC'13)
    • Place of Presentation
      アメリカ合衆国ハワイ州ハワイ島
    • Related Report
      2013 Research-status Report
  • [Presentation] 3次元アトムプローブによる炭素繊維の原子レベルでの解析

    • Author(s)
      谷口昌宏,西川治 (金沢工大)
    • Organizer
      第61回応用物理学会学術講演会
    • Place of Presentation
      青山学院大学(神奈川県相模原市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 走査型アトムプローブによる有機高分子膜(ウルシ膜)の分析

    • Author(s)
      谷口昌宏、林遼吾、西川治、小川俊夫
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学 びわこ ・くさつキャンパス(滋賀県 草津市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 走査型アトムプローブによるアミノ酸の原子レベルでの解析

    • Author(s)
      谷口 昌宏、西川 治、猪飼 篤、川村 和孝、中岡 慎太郎
    • Organizer
      第32回表面科学学術講演会
    • Place of Presentation
      東北大学 さくらホール (宮城県 仙台市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Atom Probe Analysis of Conductive Polymer

    • Author(s)
      M. Taniguchi, A. Yanagisawa, O.Nishikawa
    • Organizer
      SISS-14 in 2012 (The International symposium on SIMS and Related Techniques Base on Ion-Solid Interactions at Seikei University)
    • Place of Presentation
      Seikei University (東京都 武蔵野市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 走査型アトムプローブによる炭素繊維の原子レベルでの解析

    • Author(s)
      西川治,谷口昌宏
    • Organizer
      第60回応用物理学会春季学術講演会
    • Place of Presentation
      神奈川工科大学 (神奈川県厚木市)
    • Related Report
      2012 Research-status Report
  • [Book] マイクロビームアナリシスハンドブック (日本学術振興会マイクロビームアナリシス第141委員会編集)             (pp. 271~282. 「2.5.9 アトムプローブ電界イオン顕微鏡」の執筆を担当)2014

    • Author(s)
      斎藤弥八、大嶋忠平、越川孝範、志水隆一、二瓶好正、丸勢進、石井秀司、黒河基史、中原仁、野島雅、一村信吾、大岩烈、尾張正則、河合閏、木村健二、工藤正博、坂本哲夫、鈴木茂、斎藤光利、大門寛、高井義造、田沼繁夫、堂前和彦、畑浩一、日比野浩樹、本間芳和、水谷五郎、森田清三、松尾二郎、谷口昌宏、ほか
    • Total Pages
      708
    • Publisher
      オーム社
    • Related Report
      2014 Research-status Report
  • [Book] マイクロビームアナリシス ハンドブック(学振マイクロビームアナリシス第141委員会編集)2014

    • Author(s)
      共著
    • Total Pages
      800
    • Publisher
      オーム社
    • Related Report
      2013 Research-status Report
  • [Book] マイクロビームアナリシス ハンドブック2013

    • Author(s)
      谷口昌宏 (学振マイクロビームアナリシス第141委員会編集、分担執筆)
    • Total Pages
      800
    • Publisher
      オーム社
    • Related Report
      2012 Research-status Report
  • [Remarks] 金沢工業大学 応用化学科 谷口昌宏 研究室

    • URL

      http://www2.kanazawa-it.ac.jp/nanotech/

    • Related Report
      2014 Research-status Report
  • [Remarks] 応用化学科 (西川治・)谷口昌宏 研究室

    • URL

      http://www2.kanazawa-it.ac.jp/nanotech/

    • Related Report
      2013 Research-status Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www2.kanazawa-it.ac.jp/nanotech/

    • Related Report
      2012 Research-status Report
  • [Remarks] 研究業績

    • URL

      http://www2.kanazawa-it.ac.jp/nanotech/gyouseki.htm

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 軸性キラリティを有するPd(II)2核錯体からなる液晶物質キラルドーパント2014

    • Inventor(s)
      田村堅志、山岸晧彦、佐藤久子、北澤孝史、谷口昌宏
    • Industrial Property Rights Holder
      田村堅志、山岸晧彦、佐藤久子、北澤孝史、金沢工業大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-079713
    • Filing Date
      2014-04-08
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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