| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Shellfish poisoning is one of food poisoning that has causes financial breakdown the aquaculture industry. When the concentration of toxic substance synthesized by a specific type of plankton is beyond the regulated level, shipping of bivalves is stopped. Thus, it is important to elucidate a mechanism of the detoxification in bivalves. In this study, we studied a structural transformation of okadaic acid, a diarrhetic shellfish toxin, because the transformation was considered to be a key reaction for the detoxification. The results of our research study are 1) the structural modification proceeds only in the digestive gland of bivalve species; 2) the enzyme might be a membrane protein identified in the microsomal fraction; 3) the structural modification proceeds in various bivalve species.
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