Structural transformation of a diarrhetic shellfish toxin, okadaic acid, in scallops
| Project/Area Number |
24510291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
KONOKI Keiichi 東北大学, (連合)農学研究科(研究院), 准教授 (40292825)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 下痢性貝毒 / 解毒機構 / オカダ酸 / 変換酵素 / 酵素 / 単離・精製 / 二枚貝 / 自己耐性機構 / 酵素精製 |
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| Outline of Final Research Achievements |
Shellfish poisoning is one of food poisoning that has causes financial breakdown the aquaculture industry. When the concentration of toxic substance synthesized by a specific type of plankton is beyond the regulated level, shipping of bivalves is stopped. Thus, it is important to elucidate a mechanism of the detoxification in bivalves. In this study, we studied a structural transformation of okadaic acid, a diarrhetic shellfish toxin, because the transformation was considered to be a key reaction for the detoxification. The results of our research study are 1) the structural modification proceeds only in the digestive gland of bivalve species; 2) the enzyme might be a membrane protein identified in the microsomal fraction; 3) the structural modification proceeds in various bivalve species.
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Report
(4 results)
Research Products
(15 results)
