Search for new fluorescent natural products from medicinal plants and their properties in living cells

• Project/Area Number: 24510293
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Nihon University (2013-2015); Tokyo Medical and Dental University (2012)
• Principal Investigator: OHSAKI Ayumi 日本大学, 文理学部, 准教授 (50161360)
• Co-Investigator(Kenkyū-buntansha): FUKUYAMA Yoshiyasu 徳島文理大学, 薬学部, 教授 (70208990)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 天然蛍光物質 / 薬用植物 / アルカロイド / 蛍光イメージリング / 全合成 / 蛍光特性 / 全合成研究

Outline of Final Research Achievements

In this study, we performed screening studies of fluorescent compounds derived from tropical medicinal plants. A strongly fluorescent compound, amarastelline A, consisting of a canthin unit and a carboline unit, was isolated from Quassia amara. Its fluorescent properties in various solvents and its ability to stain the cell cytoplasm of living HeLa cells were investigated. Furthermore, the total synthesis of amarastelline A and its derivatives were studied.

Research Products

• [Journal Article] 南米産薬用植物Licaria puchury-major種子のアルカロイド成分と薬剤耐性がん細胞に対する殺細胞活性 (2015)
  • Author(s): 大崎愛弓, 宝谷尚徳，小沢正晃，岸田晶夫，小宮山寛機， 久保伊佐夫
  • Journal Title: 日本大学文理学部自然科学研究所研究紀要 Volume: 50 Pages: 295-298
  • NAID: 40020418189
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Nonpeptide Neurotrophic Agents Useful in the Treatment of Neurodegeneration Diseases such as Alzheimer’s Disease. (2015)
  • Author(s): M. Akagi, N. Matsui, H. Akae, N. Hirashima, N. Fukuishi, Y. Fukuyama, R. Akagi
  • Journal Title: J. Pharmacol. Sci. Volume: 127 Issue: 2 Pages: 155-163
  • DOI: 10.1016/j.jphs.2014.12.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Systematic Asymmetric Synthesis of All Diastereomers of (-)-Talaumidin and Their Neurotrophic Activity. (2015)
  • Author(s): Harada, K.; Kubo, M.; Horiuchi, H.; Ishii, A.; Esumi, T.; Hioki, H.; Fukuyama, Y.
  • Journal Title: J. Org. Chem. Volume: 80 Issue: 14 Pages: 7076-7088
  • DOI: 10.1021/acs.joc.5b00945
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tetranorsesquiterpenoids and Santalane-Type Sesquiterpenoids from Illicium lanceolatum and Their Antimicrobial Activity against the Oral Pathogen Porphyromonas gingivalis. (2015)
  • Author(s): Kubo, M.; Nishikawa, Y.; Harada, K.; Oda, M.; Huang, J.-M.; Domon, H.; Terao, Y.; Fukuyama, Y.
  • Journal Title: J. Nat. Prod. Volume: 78 Issue: 6 Pages: 1466-1469
  • DOI: 10.1021/acs.jnatprod.5b00237
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthesis of Jiadifenin Using Mizoroki-Heck and Tsuji-Trost Reactions. (2015)
  • Author(s): K. Harada, A. Imai, K. Uto, R. G. Carter, M. Kubo, H. Hioki, Y. Fukuyama,
  • Journal Title: Tetrahedron Volume: 71 Issue: 15 Pages: 2199-2209
  • DOI: 10.1016/j.tet.2015.02.090
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureum. (2015)
  • Author(s): M. Kubo, M. Gima, K. Baba, M. Nakai, K. Harada, M. Suenaga, Y. Matsunaga, E. Kato, S. Hosoda, Y. Fukuyama.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 25 Issue: 7 Pages: 1586-1591
  • DOI: 10.1016/j.bmcl.2015.02.005
  • Peer Reviewed / Open Access
• [Journal Article] Improved chemical synthesis, X-ray crystallographic analysis, and NMR characterization of (22R)-/(22S)-hydroxy epimers of bile adics. (2014)
  • Author(s): Omura, K.; Ohsaki, A.; Zhou, B.; Kushida, M.; Mitsuma, T.; Kobayashi, A.; Hagey, L. R.; Hofmann, A. F.; Iida,T.
  • Journal Title: Lipid Volume: 49 Issue: 11 Pages: 1169-1180
  • DOI: 10.1007/s11745-014-3955-y
  • Peer Reviewed / Open Access
• [Journal Article] Structures of six new compounds from Ligularia brassicoides. (2014)
  • Author(s): Saito, Y.; Sasaki, Y.; Ohsaki, A.; Okamoto, Y.; Gong, X.; Kuroda, C.; Tori, M.
  • Journal Title: Tetrahedron Volume: 70 Issue: 51 Pages: 9726-9730
  • DOI: 10.1016/j.tet.2014.10.003
  • Peer Reviewed / Open Access
• [Journal Article] A Lanostane Triterpenoid and Three Cholestane Sterols from <i>Tilia kiusiana</i> (2014)
  • Author(s): Shimada M.; Ozawa, M.; Iwamoto, K.; Fukuyama, Y.; Kishida, A.; Ohsaki, A
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 62 Issue: 9 Pages: 937-941
  • DOI: 10.1248/cpb.c14-00200
  • NAID: 130004684767
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access
• [Journal Article] Structure and cytotoxic evaluation of 12-oxygenated eremophilanes from Ligularia lingiana (2014)
  • Author(s): Saito, Y.; Sasaki, Y.; Komiyama, T.; Ohsaki, A.; Okamoto, Y.; Gong, X.; Kuroda, C.; Tori, M.
  • Journal Title: Tetrahedron Volume: 70 Issue: 35 Pages: 5878-5883
  • DOI: 10.1016/j.tet.2014.06.030
  • Peer Reviewed / Open Access
• [Journal Article] N-methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish (2014)
  • Author(s): Okihara, R.S.Ｎ., Saito, T., Ogata, H., Ohsaki, A., Iida, T., Asahina, K., Mitamura, K., Ikegawa, S., Hofmann, A.E., Hagey, L.R.
  • Journal Title: Steroids Volume: 80 Pages: 15-23
  • DOI: 10.1016/j.steroids.2013.11.014
  • Peer Reviewed / Open Access
• [Journal Article] 中国横断山脈地域に生育するキク科Liguraria属植物の生産するフラノエレモフィラン化合物の多様性. (2014)
  • Author(s): 黒田智明、花井亮、通元夫、岡本育子、齋藤義紀、永野肇、大崎愛弓、廣田洋、川原孝行、Xun GONG.
  • Journal Title: 有機合成化学協会誌 Volume: 72 Pages: 717-725
  • Peer Reviewed / Open Access
• [Journal Article] A New Spiroindene Pigment from the Medicinal Fungus <i>Phellinus ribis</i> (2014)
  • Author(s): Kubo, M.; Liu, Y.; Ishida, M.; Harada, K.; Fukuyama, Y.
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 62 Issue: 1 Pages: 122-124
  • DOI: 10.1248/cpb.c13-00722
  • NAID: 130003381813
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access
• [Journal Article] Chapter 2 - Chemical diversity of vibsanin-type diterpenoids and neurotrophic acitivity and synthesis of neovibsanin. (2014)
  • Author(s): M. Kubo, T. Esumi, H. Imagawa, Y. Fukuyama.
  • Journal Title: Studies in Natural Products Chemistry. Volume: 43. Issue: 43 Pages: 41-78
  • DOI: 10.1016/j.tetlet.2014.09.040
  • Peer Reviewed / Open Access
• [Journal Article] Solid-phase synthesis of benzazoles, quinazolines, and quinazolinones using an alkoxyamine linker. (2014)
  • Author(s): Yamaguchi, K.; Noda, T.; Higuchi, Y.; Aoki, N.;Yamaguchi, R.; Kubo, M.; Harada, K.; Fukuyama, Y.; Hioki. H.
  • Journal Title: Tetrahedron Lett. Volume: 55 Issue: 42 Pages: 5793-5797
  • DOI: 10.1016/j.tetlet.2014.08.095
  • Peer Reviewed / Open Access
• [Journal Article] Four new compounds from Ligularia virgaurea; isolation of eremophilane and noreremophilane sesquiterpenoids and the absolute configuration of 2a-hydroxyeremophil-11-en-9-one by the CD spectrum and DFT calculation. (2013)
  • Author(s): Y. Saito, M. Taniguchi, T. Komiyama, A. Ohsaki, Y. Okamoto, X. Gong, C. Kuroda, T. Tori
  • Journal Title: Tetrahedron Volume: 69 Pages: 8505-8510
  • Peer Reviewed
• [Journal Article] Inhibitory Effect of Erythraline on Toll-Like Receptor Signaling Pathway in RAW264.7 Cells (2013)
  • Author(s): T. Etoh, Y. P. Kim, A. Ohsaki, K. Komiyma, M. Hayashi
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 36 Issue: 8 Pages: 1363-1369
  • DOI: 10.1248/bpb.b12-00910
  • NAID: 130003361488
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] A short synthesis of (+)-bakuchiol. (2013)
  • Author(s): T. Esumi, C. Yamamoto, Y. Fukuyama
  • Journal Title: Synlett. Volume: 24 Issue: 14 Pages: 1845-1847
  • DOI: 10.1055/s-0033-1338968
  • Peer Reviewed
• [Journal Article] Total Synthesis of Bisbibenzyl Dibenzofuran Asterelin A via Intramolecular Oxidative Coupling. (2013)
  • Author(s): K. Makino, K. Harada, M. Kubo, H. Hioki, Y. Fukuyama.
  • Journal Title: Nat. Prod. Comm Volume: 8 Pages: 915-918
  • Peer Reviewed
• [Journal Article] Total synthesis of riccardin C and (±)-cavicularin via Pd-catalyzed Ar-Ar corss couplings. (2013)
  • Author(s): K. Harada, K. Makino, N. Shima, H. Okuyama, T. Esumi, M. Kubo, H. Hioki, Y. Asakawa, Y. Fukuyama.
  • Journal Title: Tetrahedron Volume: 69 Issue: 34 Pages: 6959-6968
  • DOI: 10.1016/j.tet.2013.06.064
  • Peer Reviewed
• [Journal Article] Evaluation of Constituents of Piper retrofractum Fruits on Neurotrophic Activity. (2013)
  • Author(s): Miwa Kubo
  • Journal Title: J. Nat. Prod. Volume: 76 Issue: 4 Pages: 769-773
  • DOI: 10.1021/np300911b
  • Peer Reviewed
• [Journal Article] Construction of Successive Chiral Centers Adjacent to a Chiral Tetraalkylated Quaternary Center using an Asymmetric Aldol Reaction (2013)
  • Author(s): Tomoyuki Esumi
  • Journal Title: Org. Lett. Volume: 15 Issue: 8 Pages: 3108-3111
  • DOI: 10.1021/ol400556v
  • Peer Reviewed
• [Journal Article] Total Synthesis of Bisbibenzyl Dibenzofurnan Asprelin A via Intramolecular Oxidative Coupling. (2013)
  • Author(s): K. Makino, K. Harada, M. Kubo, H. Hioki, Y. Fukuyama
  • Journal Title: Nat. Prod. Comm. Volume: 8
  • Peer Reviewed
• [Journal Article] The cytotoxic activity of diterpenoids from Isodon species. (2012)
  • Author(s): A. Ohsaki, M. Ozawa, K. Komiyama, Isobe T.
  • Journal Title: Nat. Prod. Commun. Volume: 7 Pages: 977-978
  • Peer Reviewed
• [Journal Article] Amarastelline A: A fluorescent alkaloid from Quassia amara and its properties in living cells (2012)
  • Author(s): K. Taniguchi et al
  • Journal Title: Chempluschem Volume: 77 Issue: 6 Pages: 427-431
  • DOI: 10.1002/cplu.201200016
  • Peer Reviewed
• [Journal Article] Two new norursane-type triterpenoids from Dipsacus chinensis collected in China (2012)
  • Author(s): Y. Saito et al
  • Journal Title: Chemistry Lett. Volume: 41 Issue: 4 Pages: 372-373
  • DOI: 10.1246/cl.2012.372
  • NAID: 10030544485
  • Peer Reviewed
• [Journal Article] Chemical and Genetic Study of Ligularia duciformis and Related Species in Sichuan and Yunnan Provinces of China, (2012)
  • Author(s): H. Nagano, et al.
  • Journal Title: Chemistry and Biodiversity Volume: 4 Pages: 789-805
  • Peer Reviewed
• [Journal Article] Nerve Growth Factor-Potentiating Benzofuran Derivatives from the Medicinal Fungus Phellinus ribis. (2012)
  • Author(s): Yuhong Liu, M. Kubo, Y. Fukuyama
  • Journal Title: J. Nat. Prod. Volume: 75, (12) Issue: 12 Pages: 2152-2157
  • DOI: 10.1021/np300566y
  • Peer Reviewed
• [Journal Article] Solid-phase synthesis of benzothiazoles using an alkoxyamine linker. (2012)
  • Author(s): Hideaki Hioki
  • Journal Title: Tetrahedron Lett. Volume: 53 Issue: 33 Pages: 4337-4342
  • DOI: 10.1016/j.tetlet.2012.06.008
  • Peer Reviewed
• [Journal Article] Spirocyclic nortriterpenoids with NGF-potentiating activity from the fruits of Leonurus heterophyllus (2012)
  • Author(s): Liu, Yuhong; Kubo, Miwa; Fukuyama, Yoshiyasu
  • Journal Title: Journal of Natural Products Volume: 75 Issue: 7 Pages: 1353-1358
  • DOI: 10.1021/np300287f
  • Peer Reviewed
• [Journal Article] Magnolol protects against MPTP/MPP+- induced toxicity via inhibition of oxidative stress in in vivo and in vitro models of Parkinson's disease. (2012)
  • Author(s): K. Muroyama, A. Fuji Cheng Lv, S. Kobayashi, Y. Fukuyama, Y. Mitsumoto
  • Journal Title: Parkinson's Disease Volume: Article ID 985157 Pages: 9-9
  • DOI: 10.1155/2012/985157
  • Peer Reviewed
• [Journal Article] Neurotrophic Phenylbutenoid Dimers Isolated from Zingiber purpureum Enhance Adult Hippocampal Neurogenesis in Olfactory Bulbectomized Mice (2012)
  • Author(s): 福山愛保
  • Journal Title: Neuroscience Lett. Volume: 513 Issue: 1 Pages: 72-77
  • DOI: 10.1016/j.neulet.2012.02.010
  • Peer Reviewed
• [Journal Article] Syntheses of Structurally-simplified and Fluorescently-labeled Neovibsanin Derivatives and Analysis of their Neurite Outgrowth Activity in PC12 Cells. (2012)
  • Author(s): H.Imagawa, H. Siajo, H. Yamaguchi, K. Maekwa, T. Kurisaki, H. Yamamoto, M. Nishizawa, M. Oda, M. Kaubura, M. Nagahama, J. Sakurai, M. Nakai, K. Makino, M. Ogata, H. Takahashi, Y. Fukuyama
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 22,(5) Issue: 5 Pages: 2089-2093
  • DOI: 10.1016/j.bmcl.2012.01.006
  • Peer Reviewed
• [Journal Article] Asymmetric synthesis of (－)-chicanine using a highly regioselective intramolecular Mitsunobu reaction and revision of its absolute configuration (2011)
  • Author(s): Kenichi Haradaa, Hiroki Horiuchia, Kazuma Tanabea, Rich G. Carterb, Tomoyuki Esumia, Miwa Kuboa, Hideaki Hiokic, Yoshiyasu Fukuyama
  • Journal Title: Tetrahedron Letters Volume: 52 Issue: 23 Pages: 3005-3008
  • DOI: 10.1016/j.tetlet.2011.03.154
  • Peer Reviewed
• [Presentation] Securinega suffruticosaの成分 (2016)
  • Author(s): 児玉佳之，久保美和，福山愛保，廣田洋，大崎愛弓
  • Organizer: 日本薬学会第１３６年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-26
• [Presentation] 運動神経細胞死メカニズム研究を基礎としたALS治療効果のある薬物シーズの開発 (2016)
  • Author(s): 草間ー江口國子，益子崇，廣瀬大，大崎愛弓，牧野三津子，松崎桂一，飯島洋，池上文雄，北中進
  • Organizer: 日本薬学会第１３６年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-26
• [Presentation] 中国産Salvia grandifolia およびSalvia sp.の成分研究 (2016)
  • Author(s): 川邊浩史，小宮山哲平，齋藤義紀，岡本育子，通元夫，黒田智明，影近弘之，Gong Xun, 廣田洋，大崎愛弓
  • Organizer: 日本薬学会第１３６年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-26
• [Presentation] Portulaca pilosaの成分 (2016)
  • Author(s): 原惠美，廣田洋，大崎愛弓
  • Organizer: 日本薬学会第１３６年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-26
• [Presentation] 蛍光性天然物およびその部分構造を基にした蛍光センサーの開発 (2016)
  • Author(s): 横尾英知，平野智也，大崎愛弓，影近弘之
  • Organizer: 日本薬学会第１３６年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-26
• [Presentation] 蛍光性アルカロイドアマラステリンＡの合成研究 (2016)
  • Author(s): 山根裕貴，原田研一，久保美和，大崎愛弓，福山愛保
  • Organizer: 日本薬学会第１３６年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-03-26
• [Presentation] 蛍光性天然物ニガキノン誘導体の合成と蛍光特性の解析 (2015)
  • Author(s): 横尾英知，平野智也，大崎愛弓，影近弘之
  • Organizer: 第45回複素環化学討論会
  • Place of Presentation: 早稲田大学（東京都）
  • Year and Date: 2015-11-19
• [Presentation] 蛍光性天然物ニガキノンを基にした蛍光センサーの開発研究 (2015)
  • Author(s): 横尾英知，平野智也，大崎愛弓，影近弘之
  • Organizer: 第9回バイオ関連化学シンポジウム
  • Place of Presentation: 熊本大学（熊本市）
  • Year and Date: 2015-09-10
• [Presentation] Bowdichia virgilioides 種子由来の新規フラノカッサン型ジテルペン成分 (2015)
  • Author(s): 笠原拓，遠藤裕太，原田研一，久保美和，平野智也，江藤忠洋，影近弘之，福山愛保，大崎愛弓，
  • Organizer: ５７回天然有機化合物討論会
  • Place of Presentation: 神奈川県民ホール（横浜市）
  • Year and Date: 2015-09-09
• [Presentation] New abietane diterpenoids from Salvia grandifolia (2015)
  • Author(s): Kawabe H, Komiyama T, Saito Y, Tori M, Kuroda C, Gong X, Ohsaki A,
  • Organizer: Inaugural Symposium of the Phytochemical Society of Asia 2015
  • Place of Presentation: 徳島文理大学（徳島市）
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] Search for bioactive constituents from subtropical medicinal plants, Securinega suffruticosa var. amamiensis, (2015)
  • Author(s): Kodama Y, Shimada M, Kubo M, Fukuyama Y, Ohsaki A
  • Organizer: Inaugural Symposium of the Phytochemical Society of Asia 2015
  • Place of Presentation: 徳島文理大学（徳島市）
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] Fluorescent compounds from Quassia amara (2015)
  • Author(s): Hinata N, Hirano T, Kagechica H, Ohsaki A
  • Organizer: Inaugural Symposium of the Phytochemical Society of Asia 2015
  • Place of Presentation: 徳島文理大学（徳島市）
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] Furanocassane diterpenoids from Bowdichia virgilioides (2015)
  • Author(s): Kasahara T, Natsume S, Harada K, Kubo M, Fukuyama Y, Endo Y, Ohsaki A,
  • Organizer: Inaugural Symposium of the Phytochemical Society of Asia 2015
  • Place of Presentation: 徳島文理大学（徳島市）
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] ブラジル産薬用植物Bowdichia virgilioides の種子に含まれる新規成分 (2015)
  • Author(s): 笠原拓，遠藤裕太，夏目志帆理，秋末剛吉，原田研一，久保美和，福山愛保，平野智也，影近弘之，大崎愛弓
  • Organizer: 日本化学会第９５春季年会
  • Place of Presentation: 日本大学理工学部 船橋
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] Quassia amara 由来の蛍光成分 (2015)
  • Author(s): 日向尚輝，平野智也，影近弘之，大崎愛弓
  • Organizer: 日本化学会第９５春季年会
  • Place of Presentation: 日本大学理工学部 船橋
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] 中国四川省産Salvia przewalskii およびEuphorbia griffithiiの成分研究 (2014)
  • Author(s): 塚田悠、影近弘之、斉藤紗野、大崎愛弓、斉藤義紀、岡本育子、通元夫、黒田智明、Gong Xun
  • Organizer: 日本薬学会第１３４年会
  • Place of Presentation: 熊本市総合体育館
• [Presentation] Bowdichia virgilioidesに含まれる化学成分 (2013)
  • Author(s): 大崎愛弓、遠藤裕太、秋末剛吉、原田研一、久保美和、福山愛保
  • Organizer: 第５７回 香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 埼玉大学
• [Presentation] ニガキ科に含まれる新規蛍光成分の探索 (2013)
  • Author(s): 大城佳奈子、日向尚輝、土川裕輝、黒木悠李菜、平野智也、影近弘之、大崎愛弓
  • Organizer: 第56回日本薬学会関東支部大会
  • Place of Presentation: 帝京大学薬学部
• [Presentation] シャタバリの成分と同定に関する検討 (2013)
  • Author(s): 大崎愛弓、小宮山哲平、小沢正晃、Samir K SADHU, Ahmede FIROJ, 粂田幸恵、袴塚高志、合田幸広、影近弘之、石橋正己
  • Organizer: 日本薬学会第１３３回年会
  • Place of Presentation: 横浜
• [Presentation] Bowdichia virgilioides の種子に含まれる新規成分 (2013)
  • Author(s): 遠藤裕太、原田研一、久保美和、福山愛保、秋末剛吉、影近弘之、大崎愛弓、
  • Organizer: 日本薬学会第１３３回年会
  • Place of Presentation: 横浜
• [Presentation] 中国四川省産薬用植物Salvia grandifoliaに含まれる新規化学成分 (2013)
  • Author(s): 小宮山哲平、大崎愛弓、影近弘之、黒田智明、斎藤義紀、岡本育子、通 元夫、Xun GONG,
  • Organizer: 日本薬学会第１３３回年会
  • Place of Presentation: 横浜
• [Presentation] 大環状ビスビベンジル カビクラリンの合成研究 (2013)
  • Author(s): 牧野宏章、原田研一、久保美和、福山愛保
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 中国産薬用茸 Phellinus ribis の生理活性成分研究 (2013)
  • Author(s): 石田麻美、劉玉紅、原田研一、久保美和、福山愛保
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] Talaumidin の誘導体合成と神経栄養因子様活性. (2013)
  • Author(s): 座波克圭、今井顕子、原田研一、久保美和、松井敦聡、山田恵子、赤木正明、福山愛保、
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 有機分子触媒 Hua Cat を利用したフラノステロイドの合成研究. (2013)
  • Author(s): 原田研一、Rajinikanth Lingampally、Pieter Waldenmaier、Rich G. Carter、福山愛保、
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] ジャワショウガBANGLEから得られた新規フェニルブテノイド二量体とクルクミン誘導体の構造. (2013)
  • Author(s): 久保美和、馬場皓平、原田研一、福山愛保
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] ヒオウギ（Belmacanda chinensis）種子の神経栄養因子様活性物質の探索研究. (2013)
  • Author(s): 岩瀬瑠美、原田研一、久保美和、福山愛保
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] （+)-Ascaspiroketal B A 環部構築法に関する研究. (2013)
  • Author(s): 御厨大貴、井上海容、江角朋之、豊田正夫、浅川義範、福山愛保
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 神経栄養因子活性天然物 (+)-neovibsanin B のエナンチオ選択的合成研究. (2013)
  • Author(s): 山本千尋、津川有里、江角朋之、豊田正夫、浅川義範、福山愛保
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] Salvia przewalskiiの化学成分 (2012)
  • Author(s): 塚田悠、小宮山哲平、大崎愛弓、影近弘之、大高彩、黒田智明、斎藤義紀、岡本育子、通元夫、Xun Gong
  • Organizer: 第５６回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 鹿児島
• [Presentation] Quassia amaraに含まれる新規蛍光物質の探索と生細胞への適用 (2012)
  • Author(s): 大崎愛弓、平野智也、谷口香織、滝沢進也、村田滋、岸田晶夫、影近弘之
  • Organizer: 第５６回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 鹿児島
• [Presentation] 中国四川産薬用植物Salvia grandifoliaに含まれる新規成分 (2012)
  • Author(s): 小宮山哲平、大崎愛弓、影近弘之、黒田智明、斎藤義紀、岡本育子、通元夫、Xun Gong
  • Organizer: 第５６回日本薬学会関東支部大会
  • Place of Presentation: 東京
• [Presentation] ブラジル産薬用植物マメ科Bowdichia virgilioidesの種子に含まれる化学成分 (2012)
  • Author(s): 遠藤裕太、久保美和、福山愛保、秋末剛吉、影近弘之、大崎愛弓
  • Organizer: 第５６回日本薬学会関東支部大会
  • Place of Presentation: 東京
• [Presentation] Salvia przewalskiiの化学成分研究 (2012)
  • Author(s): 塚田悠、小宮山哲平、大崎愛弓、影近弘之、大高彩、黒田智明、齋藤義紀，岡本育子、通元夫、Xun Gonｇ
  • Organizer: 日本生薬学会第59回年会
  • Place of Presentation: 木更津
• [Presentation] Quassia amara 由来の新規蛍光物質の構造と生細胞への適用 (2012)
  • Author(s): 大崎愛弓、平野智也、谷口香織、滝沢進也、村田滋、岸田晶夫、影近弘之
  • Organizer: 第7回日本ケミカルバイオロジー学会
  • Place of Presentation: 京都
• [Presentation] ジャワショウガBANGLEの神経栄養因子様活性作用 (2012)
  • Author(s): 久保美和、 仲井めぐみ、原田研一、松井敦聡、赤木正明
  • Organizer: 第15回日本補完代替医療学会
  • Place of Presentation: 東京
• [Presentation] Neurotrophic Activity of Javanese Ginger BANGLE. (2012)
  • Author(s): 福山愛保
  • Organizer: Hi Europe, Ni & NuW for 2012
  • Place of Presentation: Frankfurut, Germany
  • Invited
• [Presentation] 益母草の果実から得られたNGF作用増強活性を有するノルトリテルペノイド. (2012)
  • Author(s): 福山愛保、劉玉紅、久保美和
  • Organizer: 第55回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 鹿児島
• [Remarks] Ohsaki A. Homepage
  • URL: http://ohsakilabo.jimdo.com/
• [Remarks] 大崎愛弓ＨＰ
  • URL: http://ohsakilabo.jimdo.com/
• [Remarks] 大崎愛弓HP
  • URL: http://ohsakilabo.jimdo.com/
• [Remarks] Ayumi Ohsaki HP
  • URL: http://ohsakilabo.jimdo.com/