| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Carbohydrates play important roles in numerous physiological processes. For example, cell migration, recognition, morphogenesis, cancer cell metastasis and so on. Sialo-sugar chain is a generic term for sugar chains having a sialic acid at the non-reducing end. It has been elucidated that many sialo-sugar chains are present in cancer related carbohydrate antigens. In the present study, we succeeded the synthetic mythology of sialo-sugar chains and its probes utilizing trans glycosylation activity of neuraminidase. The system that is able to synthesize the sialo-sugar chains automatically like the peptide synthesis, though it is limited in present stage.
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