Mechanism of starfish's autotomy and a pain were related

Research Project

Project/Area Number	24510303
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Living organism molecular science
Research Institution	Tohoku Pharmaceutical University
Principal Investigator	UKAI Kazuyo 東北薬科大学, 薬学部, 助教 (60433512)
Co-Investigator(Renkei-kenkyūsha)	NAMIKOSHI Michio 東北薬科大学, 薬学部, 教授 (30189196)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	ヒトデ / 自切 / NMDA受容体 / NAD代謝系 / 再生
Outline of Final Research Achievements	Autotomy, the capacity to detach a body part, is a very characteristic defense mechanism in starfish. We identified the structure of the autotomy-promoting factor that induces autotomy: a 1:1 mixture of nicotinamide (NA) and N-methylquinolinic acid (NMQA). We characterized the molecular pathways of this process for the first time, using Asterias amurensis. Inflammatory mechanism was related to 'slow autotomy'. Active compounds with protective neurodegeneration brought shortening of arm detachment time.

Report

(4 results)