| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Steroids are widely distributed in nature and they have wide variety of bioactivities and unique polycyclic framework. In this study, the synthesis of the tetracyclic skeleton of steroids via manganese(III) and copper(II)-mediated radical polycyclization. Before starting the synthesis of tetracyclic structure, construction of tricyclic moiety was investigated. The cyclization precursor was prepared by convergent synthetic route. The domino cyclization proceeded to give the desired tricyclic product and the tetracyclic framework was also provided in the similar manner.
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