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Analysis of the molecular mechanism and identification of the novel compound that regulates Altruism

Research Project

Project/Area Number 24510306
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Living organism molecular science
Research InstitutionSophia University

Principal Investigator

SAITO TAMAO  上智大学, 理工学部, 教授 (30281843)

Co-Investigator(Kenkyū-buntansha) MORITA Naoki  国立研究開発法人産業技術総合研究所, 生物プロセス研究部門 分子生物工学研究グループ, グループ長 (60371085)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsポリケタイド / 生合成 / 利他行動 / 二次代謝産物 / 社会性アメーバ / 生理活性物質
Outline of Final Research Achievements

In order to understand the molecular mechanism of Altruistic behavior that can be seen in the social insects, we used the cellular slime mould, also known as social amoebae. In 2008, the report of a large-scale analysis of restriction enzyme mediated insertion mutants has been published, and two PKS genes were reported to be involved in Altruistic behavior. By the used of gene knockout mutants, we found out that pks2 null mutant was a Cheater mutant that differentiated more spore than its fair share, when mixed with wild type cells. Our result also suggested that the product of PKS2 was involved in the regulation of the communication between the slime mould and its environment. Pks26 null mutant was found to be a Loser mutant. As far as we know, there was no report of the Loser mutant in the cellular slime mould.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(13 results)

All 2015 2014 2013 2012

All Journal Article Presentation

  • [Journal Article] The Hybrid Type Polyketide Synthase SteelyA Is Required for cAMP Signalling in Early Dictyostelium Development.2014

    • Author(s)
      Takaaki B. Narita, Zhi-hui Chen, Pauline Schaap, Tamao Saito
    • Journal Title

      PLOS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0106634

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of Fatty Acid Synthase in the Development of <i>Dictyostelium discoideum</i>2014

    • Author(s)
      Narita TB, Kikukawa TW, Sato YG, Miyazaki SH, Morita N, Saito T
    • Journal Title

      J. Oleo Sci.

      Volume: 63 Issue: 3 Pages: 281-289

    • DOI

      10.5650/jos.ess13142

    • NAID

      130004436119

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Steely Enzymes Are Involved in Prestalk and Prespore Pattern Formation2013

    • Author(s)
      Sato YG, Kagami HN, Narita TB, Fukuzawa M and Saito T
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 77 Issue: 10 Pages: 2008-2012

    • DOI

      10.1271/bbb.130294

    • NAID

      130003381879

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 原生生物細胞性粘菌のポリケタイド生合成機構2013

    • Author(s)
      齊藤玉緒
    • Journal Title

      生化学「ミニレビュー」

      Volume: 85 Pages: 1024-1028

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 細胞性粘菌Dictyostelium discoideumにおけるpks26の機能解析2015

    • Author(s)
      松本郁加、齊藤玉緒
    • Organizer
      2015年度日本農芸化学会大会
    • Place of Presentation
      岡山大学(岡山県・岡山市)
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞性粘菌Dictyostelium discoideumにおけるO-methyltransferase2の機能解析2015

    • Author(s)
      菅笑美子、深澤汐香、北圭人、齊藤玉緒
    • Organizer
      2015年度日本農芸化学会大会
    • Place of Presentation
      岡山大学(岡山県・岡山市)
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞性粘菌のpks26の機能解析2014

    • Author(s)
      松本郁加、齊藤玉緒
    • Organizer
      日本細胞性粘菌学会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2014-10-11 – 2014-10-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] The prestalk cell inducing factor hunting in Dictyostelium discoideum2013

    • Author(s)
      Yukie Sato, Tamao Saito
    • Organizer
      Dictyostelium Christmas Meeting in UK
    • Place of Presentation
      Cambridge MRC Laboratory of Molecular Biology
    • Related Report
      2013 Research-status Report
  • [Presentation] The function of SteelyA in early development2013

    • Author(s)
      Takaaki B Narita , Tamao Saito
    • Organizer
      Dictyostelium Christmas Meeting in UK
    • Place of Presentation
      Cambridge MRC Laboratory of Molecular Biology
    • Related Report
      2013 Research-status Report
  • [Presentation] 細胞性粘菌の予定柄細胞分化誘導に関するポリケタイド合成酵素の働き2013

    • Author(s)
      佐藤有紀江、加賀美太平、齊藤玉緒
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] The prestalk inducing factor hunting in Dictyostelium discoideum2012

    • Author(s)
      Sato, YG & Saito T
    • Organizer
      Annual International Dictyostelium Meeting
    • Place of Presentation
      Madrid Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] 原生生物細胞性粘菌のポリケタイド生合成機構と産物の機能解析2012

    • Author(s)
      齊藤玉緒
    • Organizer
      第25回植物脂質シンポジウム
    • Place of Presentation
      甲南大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞性粘菌の予定柄細胞分化誘導に関するポリケタイド合成酵素の働き2012

    • Author(s)
      佐藤有紀江、齊藤玉緒
    • Organizer
      第25回植物脂質シンポジウム
    • Place of Presentation
      甲南大学
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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