Drug discovery research: Searching for a new antibiotics based on stable phospho-histidine mimics
| Project/Area Number |
24510311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Keitaro 長崎国際大学, 薬学部, 講師 (60446127)
HAGIMORI Masayori 長崎大学, 薬学部, 准教授 (40446125)
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| Research Collaborator |
KINO Toru
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ホスホヒスチジン / ペプチドライブラリー / 抗菌活性 |
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| Outline of Final Research Achievements |
The purpose of this study was searching for potential new antibiotics targeting bacterial two-component signal transduction system. Our achievements, so far are following: 1) We established stereoselective and scalable amino acid synthesis based on Schoelkopf chemistry. 2) We prepared enough quantity of the phosphor-histidine mimic. 3) Synthetic method for peptides containing the mimic is established. 4) Deprotection protocol for generating free phophoric acid is invented. 5) Rapid and cheap synthesis method for dipeptide mimics is developed. Biological assay for antibiotic activities are still on going.
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] n-vitro Anti-trypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth2016
Author(s)
K Kwofie, N Tung, M Suzuki-Ohashi, M Amoa-Bosompem, R Adegle, M Sakyiamah, F Ayertey, K Owusu, I Tuffour, P Atchoglo, K Frempong, W Anyan, T Uto, O Morinaga, T Yamashita, F Aboagye, A Appiah, R Appiah-Opong, A Nyarko, Y Yamaguchi, D Edoh, K Koram, S Yamaoka, D Boakye, N Ohta, Y Shoyama, I Ayi
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Journal Title
Antimicrobial Agents and Chemotherapy
Volume: 60
Issue: 6
Pages: 3283-3290
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Anti-Trypanosomal Activity of Diarylheptanoids Isolated from the Bark of Alnus japonica2014
Author(s)
Nguyen Huu Tung, Mitsuko Suzuki, Takuhiro Uto, Osamu Morinaga, Kofi D. Kwofie, Naa Ammah, Kwadwo A. Koram, Frederic Aboagye, Dominic Edoh, Taizo Yamashita, Yasuchika Yamaguchi, Takao Setsu, Shoji Yamaoka, Nobuo Ohta, Yukihiro Shoyama
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Journal Title
The American Journal of Chinese Medicine
Volume: 42
Pages: 1245-1260
Related Report
Peer Reviewed
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[Journal Article] Anti-trypanosomal Activity of Diarylheptanoids Isolated from the Bark of Alnus japonica Steud.2014
Author(s)
Nguyen Huu Tung, Mitsuko Suzuki, Takuhiro Uto, Osamu Morinaga, Kofi D. Kwofie, Naa Ammah, Kwadwo A. Koram, Frederic Aboagye, Dominic Edoh, Taizo Yamashita, Yasuchika Yamaguchi, Takao Setsu, Shoji Yamaoka, Nobuo Ohta and Yukihiro Shoyama
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Journal Title
The American Journal of Chinese Medicine
Volume: 42
Pages: 0-0
Related Report
Peer Reviewed
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