| Project/Area Number |
24510314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | University of Toyama |
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Principal Investigator |
Awale Suresh 富山大学, 和漢医薬学総合研究所, 准教授 (00377243)
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| Co-Investigator(Renkei-kenkyūsha) |
ESUMI HIROYASU 東京理科大学, 生命医科学研究所, 教授 (70160364)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Pancreatic cancer / PANC-1 / Antiausterity strategy / metabolomics / Biomarker / Drug Discovery / pancreatic cancer / metbolomics / NMR / anti-austerity strategy / biomarker / drug discovery / antiausterity strategy / drug Discovery / Metabolomics |
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| Outline of Final Research Achievements |
Human pancreatic cancer cell lines, such as PANC-1 have altered metabolism, which enables them to tolerate and survive under the extreme nutrient starvation condition. Search for candidates that inhibit their viability during nutrition starvation represents a novel anti-austerity strategy in anticancer drug discovery. We investigated selected medicinal plants such as Uvaria dac, Caesalpinia sappan, Artocarpus altilis as a potential source for anti-austerity agents. A total of thirty-two new compounds were isolated. The mechanism of action of selected active anti-austerity agents was investigated by proteomic and metabolomic analysis.
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