Search for the antiausterity agents induced metabolomic biomarkers associated with the tolerance of nutrition starvation in pancreatic cancer
| Project/Area Number |
24510314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | University of Toyama |
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Principal Investigator |
Awale Suresh 富山大学, 和漢医薬学総合研究所, 准教授 (00377243)
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| Co-Investigator(Renkei-kenkyūsha) |
ESUMI HIROYASU 東京理科大学, 生命医科学研究所, 教授 (70160364)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Pancreatic cancer / PANC-1 / Antiausterity strategy / metabolomics / Biomarker / Drug Discovery / pancreatic cancer / metbolomics / NMR / anti-austerity strategy / biomarker / drug discovery / antiausterity strategy / drug Discovery / Metabolomics |
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| Outline of Final Research Achievements |
Human pancreatic cancer cell lines, such as PANC-1 have altered metabolism, which enables them to tolerate and survive under the extreme nutrient starvation condition. Search for candidates that inhibit their viability during nutrition starvation represents a novel anti-austerity strategy in anticancer drug discovery. We investigated selected medicinal plants such as Uvaria dac, Caesalpinia sappan, Artocarpus altilis as a potential source for anti-austerity agents. A total of thirty-two new compounds were isolated. The mechanism of action of selected active anti-austerity agents was investigated by proteomic and metabolomic analysis.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity.2014
Author(s)
Nguyen M.T.T., Nguyen N.T., Nguyen K.D.H., Dau H.T.T., Nguyen H.X., Dang P.H., Le T.M., Phan T.H.N., Tran A.H., Nguyen B.D., Ueda J., Awale S.
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Journal Title
Planta Med
Volume: 80
Issue: 02/03
Pages: 193-200
DOI
Related Report
Peer Reviewed
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[Journal Article] Cleistanthane Diterpenes from the Seed of Caesalpinia sappan and their antiausteriy activity against PANC-1 human pancreatic cancer cell line.2013
Author(s)
Nguyen H.X., Nguyen M.T.T., Nguyen T.A., Nguyen N.Y.T., Phan D.A.T., Ho P.T., Phan T.H.N., Dang P.H., Nguyen N.T., Ueda J., Awale S.
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Journal Title
Fitoterpia
Volume: 91
Pages: 148-153
DOI
Related Report
Peer Reviewed
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