| Project/Area Number |
24530884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical psychology
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| Research Institution | Nagoya City University |
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Principal Investigator |
HASHIMOTO NOBUHIKO 名古屋市立大学, 医学(系)研究科(研究院), 助教 (20534762)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAAKI Shutaro 慶応義塾大学, 医学部, 特任准教授 (80315879)
NARUMOTO Jin 京都府立医科大学, 大学院医学研究科, 准教授 (30347463)
MIMURA Masaru 慶応義塾大学, 医学部, 教授 (00190728)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メタ認知 / 認知行動療法 / 実行機能 / 前頭葉 / 高次機能 / 強迫性障害 / VBM |
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| Outline of Final Research Achievements |
In this study, we examined the neural basis of meta-cognition in OCD patients. Next, we developed the new program of meta-cognitive intervention in behavior therapy-resistant OCD patients. .Twenty OCD patients participated in an open study testing the effectiveness of the meta-cognitive intervention. Patients with a reduction in their global Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score of 35% or greater were judged as being responsive to the treatment. Among 12 OCD patients, five OCD patients were defined as responders of the treatment. In addition, five OCD patients improved on scores of questionnaires of meta-cognition. Compared with responders (n=5), non-responders exhibited significantly worse of executive function at the time of baseline, and over-estimated the wasted time during the rituals. The new program of meta-cognitive intervention is likely to be beneficial to t behavior therapy-resistant OCD patients.
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