| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
This study aimed to study the effect of blood pressure reduction on cognitive function in rats. In this research, we used spontaneously hypertensive rats (SHR) with higher blood pressure levels based on their genetic background. We compared these animals to normal controls of the Wistar-Kyoto strain (WKY). A retention gradient between 0 and 20 seconds was determined on the basis of the number of correct responses in a working memory task (a delayed-matching-to-place task, DMTP). Their performance was compared. The number of correct responses decreased after injection of the vasodilator hydralazine (0.3 and 0.6 mg/kg) compared to the injection of a vehicle, saline. The difference between these dosages was relatively small and difference in performance in this DMTP task was not evident between SHR and WKY rats. There were some strain differences in the response latency, as an index of response speed, in some simpler learning task (e.g., autoshaping).
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