• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Application of probability theory to the generation of double-strand breaks of DNA

Research Project

Project/Area Number 24540128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General mathematics (including Probability theory/Statistical mathematics)
Research InstitutionHiroshima University

Principal Investigator

SAISHO Yasumasa  広島大学, 工学(系)研究科(研究院), 准教授 (70195973)

Co-Investigator(Kenkyū-buntansha) KANAGAWA Shuya  東京都市大学, 共通教育部, 教授 (50185899)
HATAUE Itaru  金沢大学, 理工学域電子情報学系, 教授 (50218476)
ITO Atsushi  東海大学, 工学部, 教授 (80193473)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords確率モデル / DNA / 2本鎖切断 / 放射線量 / 線エネルギー付与 / 2本鎖切断(dsb) / 放射線量依存性 / 線エネルギー付与 (LET) / DNA / 2本鎖切断(dsb)
Outline of Final Research Achievements

First, we got the dose dependence of the generation of DNA double-strand breaks (dsbs) by constructing stochastic models and published a paper of this results.
Next, we considered the double dependence of the generation of dsbs on dose and linear energy transfer (LET) by extending our previous mathematical models.
We also found that the theory of hitting times of a Brownian motion is deeply related to this problem.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (53 results)

All 2015 2014 2013 2012 Other

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (35 results) (of which Invited: 13 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Immunofluorescence observation of oxidative damage of DNA induced by heavy ions from TIARA2015

    • Author(s)
      S. Kitabatake, T. Ushiroda, R. Hirayama, Y. Furusawa, T. Funayama, Y. Yokota, Y. Okahata, A. Ito
    • Journal Title

      JAEA Takasaki Annual Report 2013

      Volume: 2013 Pages: 86-86

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymptotic behavior of solutions of some difference equations2015

    • Author(s)
      H. Takahashi, S. Kanagawa and K. Yoshihara
    • Journal Title

      Stochastic Analysis and Applications

      Volume: in press

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Dependence of global bifurcation of cavity flow on locally added random noises2014

    • Author(s)
      L. Tang and I. Hataue
    • Journal Title

      Information

      Volume: 17-9 Pages: 4299-4306

    • NAID

      40022638570

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On Dependence of Structure of Numerical Solutions of Compressible Euler Equations on Random Noises2014

    • Author(s)
      Itaru Hataue
    • Journal Title

      Theo. Appl. Mech.

      Volume: 62 Pages: 81-89

    • NAID

      130004605015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mathematical Models of the Generation of Radiation-Induced DNA Double-Strand Breaks2013

    • Author(s)
      Saisho, Y. and Ito, A
    • Journal Title

      J. Math. Biol

      Volume: 67-3 Issue: 3 Pages: 717-736

    • DOI

      10.1007/s00285-012-0567-0

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] DNA2本鎖切断生成の確率モデル2013

    • Author(s)
      税所 康正,伊藤 敦
    • Journal Title

      数理解析研究所講究録

      Volume: 1853 Pages: 202-209

    • Related Report
      2013 Research-status Report
  • [Journal Article] Dependence of Bifurcation of Flow Structure in Cavity on Numerical Conditions2013

    • Author(s)
      Ling-Xiang Tang and Itaru Hataue
    • Journal Title

      Information

      Volume: 10 Pages: 7297-7309

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The nonlinear Schrodinger equation created by the vibriation of an elastic plate and its dimensional expansion2013

    • Author(s)
      S. Kanagawa and B. T. Nohara
    • Journal Title

      Discrete and Continuous Dynamical Systems

      Volume: Supplement Volume (2013) Pages: 415-426

    • DOI

      10.3934/proc.2013.2013.415

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] OH radicals from the indirect actions of X-rays induce cell lethality and mediate the majority of the oxygen enhancement effect2013

    • Author(s)
      Ryoichi Hirayama, Atsushi Ito, Miho Noguchi, Yoshitaka Matsumoto, Akiko Uzawa, Gen Kobashi, Ryuichi Okayasu, Yoshiya Furusawa
    • Journal Title

      Radiation Research

      Volume: 180 Issue: 5 Pages: 514-523

    • DOI

      10.1667/rr13368.1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Construction of the Scanning Transmission X-ray Microscope Beamline at UVSOR2013

    • Author(s)
      T. Ohigashi, H. Arai, T. Araki, N. Kondo, E. Shigemasa, A. Ito, N. Kosugi and M. Katoh
    • Journal Title

      J. Phys. Conf. Ser

      Volume: 463巻 Pages: 12006-12006

    • DOI

      10.1088/1742-6596/463/1/012006

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Construction of the Scanning Transmission x-ray Microscope Beamline at UVSOR2013

    • Author(s)
      T. Ohigashi, H. Arai, T. Araki, N. Kondo, E. Shigemasa, A Ito, N. Kosugi and M. Katoh
    • Journal Title

      Journal of Physics: Conference Series, IOP Conference Series

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 毛髪のカルシウム含量と酸化状態のサブミクロン顕微マッピング2012

    • Author(s)
      伊藤 敦、井上敬文、竹原孝二、瀧 慶暁、篠原邦夫
    • Journal Title

      X線分析技術の進歩

      Volume: 43 Pages: 161-167

    • NAID

      40019263067

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Euler-Maruyama Approximation for the reflecting Ornshtein-Uhlenbeck Processes Using the Penalty Method2012

    • Author(s)
      S. Kanagawa
    • Journal Title

      Theoretical and Applied Mechanics Japan

      Volume: 61 Pages: 207-214

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] バイスタンダー細胞におけるDNA損傷2014

    • Author(s)
      伊藤敦、後田藤太、福嶋大、山口力、前田宗利、冨田雅典
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター,鹿児島
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] キャビティ流れにおける分岐過程への数値誤差の影響と 局所性に関する数値的研究2014

    • Author(s)
      畑上 到,唐 凌翔
    • Organizer
      日本応用数理学会2014年度年会
    • Place of Presentation
      政策研究大学院大学,東京都
    • Year and Date
      2014-09-03 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] On the mathematical models describing the generation of DNA damages by radiation2014

    • Author(s)
      Y. Saisho
    • Organizer
      ICM Satellite Conference 2014: The Fourth Asian Conference on Nonlinear Analysis and Optimization
    • Place of Presentation
      National Taiwan Normal University, Taipei, Taiwan
    • Year and Date
      2014-08-05 – 2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] How to find jump-times of a Black-Scholes model with jumps for Nikkei 225 stock index2014

    • Author(s)
      S. Kanagawa
    • Organizer
      ICM Satellite Conference 2014: The Fourth Asian Conference on Nonlinear Analysis and Optimization
    • Place of Presentation
      National Taiwan Normal University, Taipei, Taiwan
    • Year and Date
      2014-08-05 – 2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stochastic models describing the generation of dsbs of DNA by radiation2014

    • Author(s)
      Y. Saisho
    • Organizer
      The 10th AIMS Conference on Dynamical Systems, Differential Equations and Applications, Special Session 129: Qualitative and Quantitative Techniques for Differential Equations Arising in Economics
    • Place of Presentation
      Universidad Autonoma de Madrid, Madrid, Spain
    • Year and Date
      2014-07-07 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] S-continuous financial time series composed from the delta-function2014

    • Author(s)
      S. Kanagawa
    • Organizer
      The 10th AIMS Conference on Dynamical Systems, Differential Equations and Applications, Special Session 129: Qualitative and Quantitative Techniques for Differential Equations Arising in Economics
    • Place of Presentation
      Universidad Autonoma de Madrid, Madrid, Spain
    • Year and Date
      2014-07-07 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Optimal portfolios based on weakly dependent data2014

    • Author(s)
      S. Kanagawa
    • Organizer
      The 10th AIMS Conference on Dynamical Systems, Differential Equations and Applications, Special Session 129: Qualitative and Quantitative Techniques for Differential Equations Arising in Economics
    • Place of Presentation
      Universidad Autonoma de Madrid, Madrid, Spain
    • Year and Date
      2014-07-07 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遷音速流れへのノイズ付加による衝撃波の位置変動に関する 数値的研究2014

    • Author(s)
      畑上 到,白鳥昇治
    • Organizer
      日本応用数理学会環瀬戸内応用数理研究部会第17回シンポジウム
    • Place of Presentation
      愛媛大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Examples of random variables in the field of mathematical biology2013

    • Author(s)
      Y. Saisho
    • Organizer
      Taiwan-Japan Bilateral Symposium on Mathematics Education 2013
    • Place of Presentation
      National Taiwan Normal University, Taipei, Taiwan
    • Related Report
      2013 Research-status Report
  • [Presentation] 放射線による DNA2本鎖切断生成の LET 依存性を表す数理モデル2013

    • Author(s)
      税所 康正,伊藤 敦
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 楕円柱まわりの遷音速流れにおけるノイズの影響に関する数値的研究2013

    • Author(s)
      畑上 到,白鳥昇治
    • Organizer
      日本応用数理学会2013年度年会
    • Place of Presentation
      アクロス福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] How to teach a concept of probability?2013

    • Author(s)
      S. Kanagawa
    • Organizer
      Taiwan-Japan Bilateral Symposium on Mathematics Education 2013
    • Place of Presentation
      National Taiwan Normal University, Taipei, Taiwan
    • Related Report
      2013 Research-status Report
  • [Presentation] X線マイクロビーム誘発バイスタンダー応答の照射後時間依存性2013

    • Author(s)
      後田藤太、福嶋 大、伊藤 敦、前田宗利、冨田雅典
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 高LET放射線のトラック構造検出のためのDNA酸化損傷8-OHdG可視化方法の開発2013

    • Author(s)
      北畠里実、上野瑞己、伊藤敦、高瀬信宏、亀山洋子、篠生環、宮沢正樹、石井恭正、石井直明、平山亮一、古澤佳也、岡畑恵雄
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 3種の生物の補食・競争数学モデルにおける 種々のパラメータ依存性に関する研究2013

    • Author(s)
      畑上 到,和泉 明憲
    • Organizer
      日本応用数理学会環瀬戸内 応用数理研究部会第16回シンポジウム
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 圧縮性オイラー方程式の数値解の構造へのランダムなノイズ の影響について2013

    • Author(s)
      畑上 到
    • Organizer
      第62回理論応用力学講演会
    • Place of Presentation
      東京工業大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Study of the Effect of Numerical Conditions on Bifurcation Region in Fluid Simulations2013

    • Author(s)
      Lingxiang Tang and Itaru Hataue
    • Organizer
      The Sixth International Conference on Information
    • Place of Presentation
      Hotel Arcadia Ichigaya, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Some stochastic approaches for biological problems2012

    • Author(s)
      Y. Saisho
    • Organizer
      The 8th International Conference on Differential Equations and Dynamical Systems
    • Place of Presentation
      University of Waterloo, Ontario, Canada
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 低 LET 放射線による DNA 2本鎖切断生成過程の確率モデ ル2012

    • Author(s)
      伊藤 敦,税所 康正
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] DNA 2本鎖切断生成の確率モデル2012

    • Author(s)
      税所 康正,伊藤 敦
    • Organizer
      2012 年度京都大学数理 解析研究所共同利用研究集会:第9回「生物数学の理論とその応用」
    • Place of Presentation
      京都大学数 理解析研究所
    • Related Report
      2012 Research-status Report
  • [Presentation] 放射線による DNA 2本鎖切断生成の確率モデルについて2012

    • Author(s)
      税所 康正,伊藤 敦
    • Organizer
      バ イオメディカル・ファジィ・システム学会第 25 回年次大会
    • Place of Presentation
      東京都市大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Construction of the Scanning Transmission x-ray Microscope Beamline at UVSOR2012

    • Author(s)
      T. Ohigashi, H. Arai, T. Araki, N. Kondo, E. Shigemasa, A Ito, N. Kosugi and M. Katoh
    • Organizer
      11th International Conference on X-ray Microscopy
    • Place of Presentation
      Shanghai, China
    • Related Report
      2012 Research-status Report
  • [Presentation] マイクロ・ナノイメージングと生体機能研究会のアクティビティ2012

    • Author(s)
      伊藤 敦、百生 敦
    • Organizer
      SPring-8シンポジウム2012
    • Place of Presentation
      大阪大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 酸素効果のメカニズムにおける化学的因子と生物学的因子2012

    • Author(s)
      平山 亮一、伊藤 敦、安藤 興一、古澤 佳也
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Limit Theorems for Hilbert Space Valued Random Variables and their Applications to Investigation of Asymptotic Behaviors of Symmetric Statistics2012

    • Author(s)
      S. Kanagawa
    • Organizer
      The 8th International Conference on Differential Equations and Dynamical Systems
    • Place of Presentation
      University of Waterloo, Ontario, Canada
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 放射線による DNA 2本鎖切断生成を表現する確率モデルについて

    • Author(s)
      税所 康正
    • Organizer
      第 50 回放射線影響懇話会
    • Place of Presentation
      佐賀大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 放射線による DNA 切断生成の数理モデル

    • Author(s)
      税所 康正,伊藤 敦
    • Organizer
      第 23 回日本数理 生物学会大会・企画シンポジウム「放射線によるDNA損傷問題の周辺 ― 数理モ デルの可能性と役割」
    • Place of Presentation
      静岡大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 高LET放射線による8-OHdG生成の評価

    • Author(s)
      北畠里実、高瀬信宏、伊藤 敦、平山亮一、古澤佳也、岡畑恵雄
    • Organizer
      第9回イオンビーム育種研究会大会
    • Place of Presentation
      若狭湾エネルギーセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] SPring-8研究会活動の活性化に向けた研究領域の将来ビジョンーイメージング分野―

    • Author(s)
      伊藤 敦
    • Organizer
      SPring-8シンポジウム2013
    • Place of Presentation
      京都大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] マイクロ・ナノイメージングと生体機能研究会のアクティビティ

    • Author(s)
      伊藤 敦、百生 敦
    • Organizer
      SPring-8シンポジウム2013
    • Place of Presentation
      京都大学
    • Related Report
      2013 Research-status Report
  • [Presentation] セミ類の発音生態の問題点 - 概論から数理的取り扱いまで -

    • Author(s)
      税所 康正
    • Organizer
      日本音響学会関西支部 第 8 回動物音響談話会
    • Place of Presentation
      同志社大学生命医科学部
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 生体試料の軟X線スペクトロスコピー

    • Author(s)
      伊藤 敦
    • Organizer
      UVSOR研究会、STXM Users Meeting
    • Place of Presentation
      岡崎
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 軟X線走査型顕微鏡(STXM)による生体試料観察への期待

    • Author(s)
      伊藤 敦
    • Organizer
      UVSORシンポジウム2012
    • Place of Presentation
      岡崎
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] The Nonlinear Schr\"{o}dinger Equation Propagating on an Elastic Plate

    • Author(s)
      S. Kanagawa, B. T. Nohara
    • Organizer
      The International Conference on the Theory, Methods and Applications of Nonlinear Equations
    • Place of Presentation
      Texas A&M University, Kingsville, Texas, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 確率微分方程式の離散化とその誤差評価について

    • Author(s)
      金川 秀也
    • Organizer
      第62回理論応用力学講演会
    • Place of Presentation
      東京工業大学
    • Related Report
      2012 Research-status Report
  • [Book] 改訂版 日本産セミ科図鑑2015

    • Author(s)
      林 正美,税所 康正
    • Total Pages
      224
    • Publisher
      誠文堂新光社
    • Related Report
      2014 Annual Research Report
  • [Book] 数理工学社2014

    • Author(s)
      畑上 到
    • Total Pages
      232
    • Publisher
      工学基礎 フーリエ解析とその応用[新訂版]
    • Related Report
      2014 Annual Research Report
  • [Book] 理工系学生のための確率・統計講義2014

    • Author(s)
      金川秀也、吉田稔、堀口正之
    • Total Pages
      168
    • Publisher
      培風館
    • Related Report
      2014 Annual Research Report
  • [Remarks] 税所ホームページ

    • URL

      http://home.hiroshima-u.ac.jp/saisho/index-j.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 税所ホームページ

    • URL

      http://home.hiroshima-u.ac.jp/saisho/index-j.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi