| Project/Area Number |
24540539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plasma science
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIDE Takuichiro Kumamoto University, Department of Neurosurgery, Assistant Professor (40421820)
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| Research Collaborator |
MENEZES Viren
MOOSAVINEJAD Seyedehfatemeh
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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| Keywords | パルスパワー / バイオエレクトリクス / 衝撃波 / DNA /薬剤/ワクチンデリバリー / DNA/薬物送達 / 高速可視化 / プラズマ / 針自由な薬物送達 / プラズマ応用 / メディカルアプリケーション |
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| Outline of Final Research Achievements |
The research aimed to investigate novel techniques using pulsed power and micro-plasma for developing a shock wave assisted non-invasive method for DNA/drug/vaccine delivery.According to the research plan, design and construction of the model system, experimental analysis and optimization of the techniques, tissue model and in-vitro evaluation of the delivery, and skin model non-invasive needle free delivery, have been performed.
Interesting results from the research have been obtained. The results include a new high efficiency micro-plasma micro/nano-particle delivery system, novel impulsive acceleration and rapid motion of free surface for DNA/drug/vaccine delivery, and new needle-free drug/vaccine delivery using pulsed power shock wave. The research outcome have been published in leading scientific journals, including PLoS one, Applied Physics Letter, Theranostics, and Biotechnology & Bioengineering Journals.
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