| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Helicenes and heterohelicenes are well-known as helically twisted compounds like a pattern of snail. Thus, helicenes are chiral and the development of catalytic asymmetric synthesis of their right-handed and left-handed isomers is a very important subject in the research field of organic synthetic chemistry and materials science. Against to this background, we have tried to develop unprecedented catalytic asymmetric synthesis of novel heterohelicenes in the present study. In consequent, we found some new "domino" cyclization reactions, in which multiple bonds are formed one after another in one pot literally like "dominoes". These results should be very promising to provide new methods for the synthesis of a variety of heterohelicenes, which are otherwise difficult to synthesize.
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