Synthetic Studies of Cyclic Depsipeptide, Grassypeptolides from Marine Cyanobacteria
| Project/Area Number |
24550064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
NAKAMURA Yutaka 新潟薬科大学, 応用生命科学部, 教授 (20267652)
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| Research Collaborator |
MIYAKOSHI Asami
AKATSUKA Kota
KOBAYASHI Kazuya
SAITO Tatsuki
ISHIDA Kyoka
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 合成有機化学 / 天然物化学 / 天然物合成 / フェイズタグ法 / 迅速合成 |
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| Outline of Final Research Achievements |
Grassypeptolides are cytotoxic cyclic depsipeptides isolated from marine cyanobacteria. A synthesis of a southern tetrapeptide fragment towards the total synthesis of grassypeptolides has been achieved using a new hydrophobic thiol protecting group, 4,4'-bis(dococyloxy)trityl group (HTrt). The synthetic HTrt protected intermediates were easily isolated by precipitation with polar solvent such as acetonitrile. The target tetrapeptide was obtained in 63 % overall yield and high purity from Fmoc-Cys(HTr)-OAll (6 steps) without column chromatographic purification.
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Report
(5 results)
Research Products
(6 results)
