| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Outline of Final Research Achievements |
Grassypeptolides are cytotoxic cyclic depsipeptides isolated from marine cyanobacteria. A synthesis of a southern tetrapeptide fragment towards the total synthesis of grassypeptolides has been achieved using a new hydrophobic thiol protecting group, 4,4'-bis(dococyloxy)trityl group (HTrt). The synthetic HTrt protected intermediates were easily isolated by precipitation with polar solvent such as acetonitrile. The target tetrapeptide was obtained in 63 % overall yield and high purity from Fmoc-Cys(HTr)-OAll (6 steps) without column chromatographic purification.
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