Synthesis, Reactivity, and Spectroscopic Studies of Multi-copper Enzyme Models
| Project/Area Number |
24550080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | University of Hyogo (2014)
Kyushu University (2012-2013) |
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Principal Investigator |
OHTA Takehiro 兵庫県立大学, 生命理学研究科, 助教 (70509950)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生体模倣金属錯体 / マルチ銅酵素 / 酸素活性化 / 分子触媒 / 生体分子 / 燃料電池 / 銅酸素錯体 |
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| Outline of Final Research Achievements |
New multi-copper enzyme model complexes, and related dioxygen activating enzyme model complexes were synthesized. Dioxygen binding and activation mechanism were studied with characterizing dioxygen binding reaction intermediates using spectroscopic methods. Reactivity of these enzyme model complexes were studied by electrochemical dioxygen reduction reaction. These studies contribute to energy conversion chemistry relating fuel cell system, unrevealing reaction mechanism of dioxygen activating enzymes.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Nuclear Resonance Vibrational Spectroscopic and Computational Study of High-valent Diiron Complexes Relevant to Enzyme Intermediates2013
Author(s)
K. Park, C. B. Bell III, L. V. Liu, D. Wang, G. Xue, T. Kwak, S. D. Wong, K. M. Light, J. Zhao, E. E. Alp, Y. Yoda, M. Saito, Y. Kobayashi, T. Ohta, M. Seto, L. Que Jr, E. I. Solomon
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 110
Issue: 16
Pages: 6275-6280
DOI
Related Report
Peer Reviewed
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[Journal Article] Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis2013
Author(s)
Nomura, J., Hashimoto, H., Ohta, T., Hashimoto, Y., Wada, K., Naruta, Y., Oinuma, K-I., & Kobayashi, M.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 110
Issue: 8
Pages: 2810-2815
DOI
Related Report
Peer Reviewed
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[Journal Article] Axial ligand effects on vibrational dynamics of iron in heme carbonyl studied by nuclear resonance vibrational spectroscopy2012
Author(s)
Ohta, T., Liu, J.-G., Saito, M., Kobayashi, Y., Yoda, Y., Seto, M., Naruta, Y.
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Journal Title
Journal of Physical Chemistry B
Volume: 116
Issue: 47
Pages: 13831-13838
DOI
Related Report
Peer Reviewed
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