Specific reaction of dendrimers at liquid/liquid interfaces and its application to electrochemical separation and detection systems

• Project/Area Number: 24550097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: NAGATANI Hirohisa 金沢大学, 物質化学系, 准教授 (90346297)
• Co-Investigator(Kenkyū-buntansha): IMURA Hisanori 金沢大学, 理工研究域物質化学系, 教授 (60142923)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: デンドリマー / 分子包接 / 液液界面 / イオン移動 / 界面吸着 / 電位変調蛍光分光法 / ドラッグデリバリー / デンドリマ- / 包接 / 電位変調分光法

Outline of Final Research Achievements

Electrochemical control of liquid/liquid distribution of ionic species through specific interactions with the dendrimer and application of photofunctionalized dendrimers as a spectrophotometric reagent were studied by means of spectroelectrochemical techniques. The mechanistic analysis of charge transfer reactions across the liquid/liquid interface demonstrated that the encapsulation behavior of ions into the dendrimer significantly depends on the molecular size and charged state of the dendrimer. It was also indicated that the axial-coordinations of the dendrimer to the metal center of encapsulated species could enhance the ion association stability. In addition, the photofunctionalized dendrimers obtained from the hybridization with luminescent gold nanodots and chemical modifications were examined as separation and spectrophotometric reagents for metal ions in liquid/liquid systems.

Research Products

• [Journal Article] In Situ Spectroscopic Characterization of Porphyrins at Liquid Interfaces (2014)
  • Author(s): Hirohisa Nagatani
  • Journal Title: Handbook of Porphyrin Science Volume: 34 Pages: 51-96
  • DOI: 10.1142/9789814417297_0013
  • ISBN: 9789814425100
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Combined use of two membrane-potential-sensitive dyes for determination of the Galvani potential difference across a biomimetic oil/water interface (2014)
  • Author(s): Tatsuya Yoshimura, Hirohisa Nagatani, Toshiyuki Osakai
  • Journal Title: Anal. Bioanal. Chem. Volume: 406 Issue: 14 Pages: 3407-3414
  • DOI: 10.1007/s00216-014-7776-x
  • Peer Reviewed
• [Journal Article] Spectroelectrochemical characterization of dendrimer-porphyrin associates at polarized liquid|liquid interfaces (2014)
  • Author(s): H. Sakae, H. Nagatani, K. Morita, H. Imura
  • Journal Title: Langmuir Volume: 30(3) Issue: 3 Pages: 937-945
  • DOI: 10.1021/la404079m
  • NAID: 120005411659
  • Peer Reviewed
• [Journal Article] Coordination structure of bromide ions associated with hexyltrimethylammonium cations at liquid/liquid interfaces under potentiostatic control as studied by total-reflection X-ray absorption fine structure (2014)
  • Author(s): H. Nagatani, M. Harada, H. Tanida, H. Sakae, H. Imura
  • Journal Title: The Journal of Chemical Physics Volume: 140(10) Issue: 10
  • DOI: 10.1063/1.4867899
  • Peer Reviewed
• [Journal Article] Interfacial self-assembly of water-soluble cationic porphyrins for the reduction of oxygen to water (2012)
  • Author(s): A. J. Olaya, D. Schaming, P. F. Brevet, H. Nagatani, H. J. Xu, M. Meyer, H. H. Girault
  • Journal Title: Angewandte Chemie - International Edition Volume: 51 Issue: 26 Pages: 6447-6451
  • DOI: 10.1002/anie.201202266
  • Peer Reviewed
• [Journal Article] Potential-modulated fluorescence spectroscopy of zwitterionic and dicationic membrane-potential-sensitive dyes at the 1,2-dichloroethane/water interface (2012)
  • Author(s): T. Osakai, T. Yoshimura, D. Kaneko, H. Nagatani, S. H. Son, Y. Yamagishi, K. Yamada
  • Journal Title: Analytical and Bioanalytical Chemistry Volume: 404(3) Issue: 3 Pages: 785-792
  • DOI: 10.1007/s00216-012-6199-9
  • Peer Reviewed
• [Presentation] 液液界面における生体関連物質の吸着反応挙動に及ぼすデンドリティック分子の効果 (2014)
  • Author(s): 坂江広基, 永谷広久, 森田耕太郎, 井村久則
  • Organizer: 第60回ポーラログラフィーおよび電気分析化学討論会
  • Place of Presentation: 京都
  • Year and Date: 2014-11-16
• [Presentation] デンドリティック分子共存下の液液界面における薬剤分子のイオン移動・吸着反応挙動 (2014)
  • Author(s): 坂江広基, 永谷広久, 森田耕太郎, 井村久則
  • Organizer: 日本分析化学会第63年会
  • Place of Presentation: 広島
  • Year and Date: 2014-09-18
• [Presentation] 新規な in situ 分光電気化学測定法を用いた液液界面吸着化学種の状態分析 (2014)
  • Author(s): 永谷広久
  • Organizer: ソフト界面科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-13
  • Invited
• [Presentation] Ion Transfer and Adsorption Behavior of Organic Ions Associated with PAMAM Dendrimers at Liquid|Liquid Interfaces (2014)
  • Author(s): Hiroki Sakae, Hirohisa Nagatani, Kotaro Morita, Hisanori Imura
  • Organizer: 65th Annual Meeting of the International Society of Electrochemistry
  • Place of Presentation: Lausanne, Switzerland
  • Year and Date: 2014-09-01
• [Presentation] Spectroelectrochemical Characterization of Ionic Dyes at Liquid|Liquid Interfaces by Polarization-Modulation Total Internal Reflection Fluorescence Spectroscopy (2014)
  • Author(s): Hirohisa Nagatani, Sho Yamamoto, Kotaro Morita, Hisanori Imura
  • Organizer: 65th Annual Meeting of the International Society of Electrochemistry
  • Place of Presentation: Lausanne, Switzerland
  • Year and Date: 2014-09-01
• [Presentation] PAMAMデンドリマー共存下の液液界面におけるフラビン化合物の吸着反応機構 (2014)
  • Author(s): 坂江広基, 永谷広久, 森田耕太郎, 井村久則
  • Organizer: 第75回分析化学討論会
  • Place of Presentation: 山梨
  • Year and Date: 2014-05-23
• [Presentation] Spectroelectrochemical Analysis of Encapsulation Behavior of Anionic Porphyrins in PAMAM Dendrimers at Liquid|Liquid Interfaces (2013)
  • Author(s): H. Sakae, H. Nagatani, K. Morita, H. Imura
  • Organizer: ASIANALYSIS XII
  • Place of Presentation: 九州大学
• [Presentation] Total-Reflection XAFS Analysis at Polarized Liquid/Liquid Interfaces (2013)
  • Author(s): H. Nagatani, M. Harada, H. Tanida, H. Sakae, H. Imura
  • Organizer: ASIANALYSIS XII
  • Place of Presentation: 九州大学
• [Presentation] 液液界面におけるPAMAMデンドリマーのアニオン性ポルフィリンに対する分子包接挙動の分光電気化学解析 (2013)
  • Author(s): 坂江広基，永谷広久，森田耕太郎，井村久則
  • Organizer: 日本分析化学会第62年会
  • Place of Presentation: 近畿大学
• [Presentation] 全内部反射偏光変調蛍光分光法による液液界面吸着化学種の配向特性と動的挙動の高感度解析 (2013)
  • Author(s): 山本 翔，永谷広久，森田耕太郎，井村久則
  • Organizer: 日本分析化学会第62年会
  • Place of Presentation: 近畿大学
• [Presentation] 蛍光性デンドリマーの発光特性と液液界面における反応挙動 (2013)
  • Author(s): 家中杏奈，永谷広久，森田耕太郎，井村久則
  • Organizer: 日本分析化学会第62年会
  • Place of Presentation: 近畿大学
• [Presentation] アミノ末端PAMAMデンドリマーによるアニオン性ポルフィリンの分子包接と液液界面における反応挙動 (2012)
  • Author(s): 坂江広基，永谷広久，森田耕太郎，井村久則
  • Organizer: 第72回分析化学討論会
  • Place of Presentation: 鹿児島大学
• [Presentation] 液液界面における金コア－銀シェルナノ粒子の光電流増幅効果 (2012)
  • Author(s): 永谷広久，吉田昇平，増富千種，相樂隆正，森田耕太郎，井村久則
  • Organizer: 第72回分析化学討論会
  • Place of Presentation: 鹿児島大学
• [Presentation] 液液界面における電荷移動・吸着反応機構の分光電気化学解析 (2012)
  • Author(s): 永谷広久
  • Organizer: 第31回分析化学中部支部夏期セミナー
  • Place of Presentation: 信州大学
  • Invited
• [Presentation] 液液界面におけるアニオン性ポルフィリン―デンドリマー会合体の分光電気化学解析 (2012)
  • Author(s): 坂江広基，永谷広久，森田耕太郎，井村久則
  • Organizer: 第58回ポーラログラフィーおよび電気分析化学討論会
  • Place of Presentation: 東京
• [Presentation] 液液界面における電荷移動・吸着反応機構の分光電気化学解析
  • Author(s): 永谷広久
  • Organizer: 2013年度第2回関西電気化学研究会
  • Place of Presentation: 大阪市立大学
  • Invited
• [Presentation] 金属ナノ粒子共存下の液液界面における不均一光誘起電移動反応検討
  • Author(s): 安藤太一，吉田昇平，永谷広久，森田耕太郎，井村久則
  • Organizer: 平成２５年度日本化学会北陸地区講演会と研究発表会
  • Place of Presentation: 北陸先端科学技術大院大学
• [Remarks] 金沢大学理工学域物質化学類化学コース分析化学研究室
  • URL: http://chem.s.kanazawa-u.ac.jp/anal/
• [Remarks] 金沢大学理工学域物質化学類化学コース 分析化学研究室
  • URL: http://chem.s.kanazawa-u.ac.jp/anal/index.html