| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We have developed new methods for the generation of putative palladacyclobutene intermediates and palladium carbenoid intermediates from α-metalloid-substituted σ-allylpalladium intermediates. These intermediates then undergo stereoselective cyclopropanation of strained alkenes and self-dimerization of palladium carbenoid intermediates, respectively. Furthermore, the three-component reaction proceeded to provide (Z)-anti-homoallylic alcohols with high diastereoselectivities and high level of alkene stereocontrols if the metalloid-substituted allylacetates, aldehydes, and organoboranes are treated in the presence of palladium catalyst. The present reaction is believed to proceed via an allylation of aldehydes followed by coupling reaction of vinylpalladium intermediates with organoboranes. Thus, we have demonstrated that α-metalloid-substituted π-allylpalladium intermediates can be used for carbon-carbon bond forming-reaction other than allylation reactions.
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