| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
The enantioselective addition of conventional organometallic reagents, such as organolithium, organozinc halides, organoboron, and organoaluminum reagents, to aldehydes is realized by the catalysis of chiral titanium complex derived from H8-BINOL derivatives bearing a bulky aryl group at the 3-position. As these organometallic reagents can be prepared readily from commercial precursors, a variety of enantiomerically enriched secondary alcohols are now available in a one-step reaction. The reaction of organozinc halides and organoboron reagents bearing functional group provides an access to the poly-functionalized chiral secondary alcohols that are often utilized in the asymmetric synthesis of pharmaceuticals.
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