Development of Catalytic Method for Enantioselective Addition of Conventional Organometallic Reagents
Project/Area Number |
24550118
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Synthetic chemistry
|
Research Institution | Kyoto Institute of Technology |
Principal Investigator |
HARADA Toshiro 京都工芸繊維大学, 工芸科学研究科, 教授 (30135628)
|
Co-Investigator(Kenkyū-buntansha) |
KUSUKAWA Takahiro 京都工芸繊維大学, 工芸科学研究科, 准教授 (70300720)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 合成化学 / 触媒 / 不斉合成 / 触媒反応 / 不斉付加 / 不斉触媒 / 不斉付加反応 |
Outline of Final Research Achievements |
The enantioselective addition of conventional organometallic reagents, such as organolithium, organozinc halides, organoboron, and organoaluminum reagents, to aldehydes is realized by the catalysis of chiral titanium complex derived from H8-BINOL derivatives bearing a bulky aryl group at the 3-position. As these organometallic reagents can be prepared readily from commercial precursors, a variety of enantiomerically enriched secondary alcohols are now available in a one-step reaction. The reaction of organozinc halides and organoboron reagents bearing functional group provides an access to the poly-functionalized chiral secondary alcohols that are often utilized in the asymmetric synthesis of pharmaceuticals.
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Report
(4 results)
Research Products
(20 results)