| Budget Amount *help |
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Outline of Final Research Achievements |
The molybdenum-catalyzed asymmetric ring-closing metathesis (ARCM) of the various Cs-symmetric (π-arene)chromium substrates proceeded smoothly and the corresponding bridged planar-chiral (π-arene)chromium complexes were obtained in excellent yields with excellent enantioselectivity of up to >99% ee. With a proper substituent, such as N-indolyl or 1-naphthyl, at the 2-positions of the η6-1,3-diisopropenylbenzene ligands, both biarylic axial chirality and π-arene-based planar-chirality could be simultaneously induced in the ARCM products via the double desymmetrization. The axial chirality thus induced was retained even after the removal of the chromium-carbonyl fragment, and the metal-free axially chiral biaryl/heterobiaryl compounds were obtained in up to >99% ee with complete retention of the enantiomeric purity. The overall protocol presented in this report can be regarded as a novel method of catalytically preparing axially chiral heterobiaryls/biaryl
|
