| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Direct functionalization of aliphatic alcohols was investingated. α-Alkylation of carbonyl compounds, such as ketones, amides, and acetonitrile, using primary aliphatic alcohols was effectively catalyzed by RuHCl(CO)(PPh3)3. The present reaction would proceed via RuH-catalyzed transfer dehydrogenation of alcohols to aldehydes, which then undergo base promoted aldol condensation with carbonyl compounds to give α,β-unsaturated compounds. Finally transfer hydrogenation of thus formed α,β-unsaturated compounds with alcohols would provide the α-alkylated products. RuHCl(CO)(PPh3)3 was also found to be effective for selective olefin isomerization of protected homoallyl alcohols. The reaction of homoallyl carbonate with malonic acid esters gave coupling product via sequential olefin isomerization and allylic alkylation reaction.
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