| Budget Amount *help |
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
With an aim to discover straightforward synthetic routes of highly functionalized bioactive molecules and to develop novel continuous reactions with single solvents or reagents, the following researches were conducted. Firstly, divergent total syntheses of geranyl resorcylates derived from the fruiting bodies of Hericium erinaceum were achieved by employing a CuBr2-mediated one-pot multi-functionalization reaction as a key reaction. Secondly, a straightforward synthetic route of cis-fused bicyclic ethers with a stereospecific ring contraction reaction was developed. This synthetic method was extended to the synthesis of brominated acetogenins derived from Laurencia species. Thirdly, applicability of cyclopentyl methyl ether (CPME) as a radical reaction solvent was assessed. The research led to the development of a highly efficient one-pot reaction consisting of a radical addition, a cross coupling, and an organometallic addition with CPME as a single reaction solvent.
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