| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
As the allylation of aldehydes via Allyl-Transfer reaction takes place by stable carbon allyl donors without using unstable organometallic allylic reagents, not only chiral allyl donors for asymmetric synthesis but also functionalized chiral allyl donors for straightforward synthesis of useful organic compounds such as bioactive natural compounds are available. Preparation of an optically active homoallylic alcohol is essential to obtain a chiral carbon allyl donor. We discovered that chiral allyl donors were available via Yamamoto's catalytic asymmetric epoxidation of homoallylic alcohols, although traditional method such as Sharpless AE did not give a satisfactory result. Now, straightforward synthesis of useful compounds is in progress by using newly prepared carbon allyl donors.
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