| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Monosaccharides like glucose have a foldable hexagonal structure. They can be exploited as a component of motional molecular devices, if we can control the folding structure by a signal molecule. We synthesized a monosaccharide with two long methylene chains that can change structures from linear to parallel chains by zinc ion. This monosaccharide with zinc ion forms a lipid bilayer structure by aggregation like cell membrane lipids, enabling incorporation of a lipophilic substance. In acidic conditions, this liposome structure is decomposed releasing the inner substances, because the parallel chain is turned back into the linear chain. The stimuli responsive liposome can be a new drug delivery system.
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