| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The following schemes in the fibrin gel formation process were strongly suggested by the SPR measurements using recombinant (and mutated) fibrinogen fragment corresponding to the N-terminal region of fibrinogen Bβ chain: 66 amino acid residues in the N-terminal region of fibrinogen Bβpolypeptide chain (BβN) play an essential role in the fibrin gel formation through interacting with the distal D-regions of fibrinogen. The central factor in that interaction is the unordered region with high mobility around Bβ44R, especially Bβ44R contributes notably to the interaction. N-linked carbohydrate chain inhibitingly affects the interaction between BβN and D-region, thus suppresses the lateral aggregation of protofibrils.
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