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Supression of wall shear stress inside cerebral aneurysm at bifurcation of anterior cerebral artery by stent

Research Project

Project/Area Number 24560208
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fluid engineering
Research InstitutionChiba University (2014)
Shibaura Institute of Technology (2012-2013)

Principal Investigator

YAMAGUCHI RYUHEI  千葉大学, 工学(系)研究科(研究院), 研究員 (90103936)

Co-Investigator(Kenkyū-buntansha) TANAKA Gaku  千葉大学, 大学院工学研究科, 准教授 (20292667)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords脳動脈瘤 / 分岐 / 壁せん断応力 / ステント / 血行力学 / 動脈瘤 / PIV / バイメカニクス / 弾性壁 / 脳血管 / 流れの可視化 / バイオメカニクス
Outline of Final Research Achievements

The effect of a simple bare metal stent on repression of wall shear stress inside a model cerebral aneurysm was experimentally investigated by two dimensional particle image velocimetry in vitro. The flow model simulated a cerebral aneurysm induced at the apex of bifurcation between the anterior cerebral artery and the anterior communicating artery. Wall shear stress was investigated using both stented and non-stented models to assess the simple stent characteristics. The flow behavior inside the stented aneurysm sac was unusual and wall shear stress was much smaller inside the aneurysm sac. Stent placement effectively repressed the temporal and spatial variations, and the magnitude of wall shear stress. Hence, there is an effective possibility that would retard the progress of cerebral aneurysms by even simple stent.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) Book (1 results)

  • [Journal Article] Repression of wall shear stress inside cerebral aneurysm at bifurcation of anterior cerebral artery by stents2015

    • Author(s)
      Ryuhei Yamaguchi、Gaku Tanaka、Hao Liu、Hiroshi Ujiie
    • Journal Title

      Heart and Vessels

      Volume: 30 Issue: 4 Pages: 1-6

    • DOI

      10.1007/s00380-015-0665-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ステントによる側壁脳動脈瘤内流れの可視化と閉塞現象、可視化情報学会論文集2013

    • Author(s)
      金子誠、小泉泰己、氏家弘、山口隆平
    • Journal Title

      可視化情報学会論文集

      Volume: 33 Pages: 1-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The effect of inlet waveforms on computational hemodynamics in intracranial aneurysms2015

    • Author(s)
      Lijian Xu, Atsushi Saitoh, Ryuhei Yamaguchi and Hao Liu
    • Organizer
      4th International Conference on Computational and Mathematical Biomedical Engineering
    • Place of Presentation
      Paris, France
    • Year and Date
      2015-06-28 – 2015-07-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳動脈瘤内流れに及ぼす血流量波形の影響2015

    • Author(s)
      酒井秀幸、田中学、山口隆平
    • Organizer
      日本機械学会第27回バイオエンジニアリング講演会論文集
    • Place of Presentation
      新潟朱鷺コンベンションセンター
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Simulated-based prediction of occlusion inside cerebral aneurysm at bifurcation of anterior communicating artery2014

    • Author(s)
      Xu, L., R. Yamaguchi, H. Liu
    • Organizer
      7th World Congress of Biomechanics
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 弾性壁動脈瘤モデルの壁せん断応力の変動2014

    • Author(s)
      徐利建、山口隆平、劉浩、氏家弘
    • Organizer
      第37回日本バイオレオロジー学会年会抄録集
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2014-06-05 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 拍動流中にある弾性壁動脈瘤モデルの壁せん断応力の変動2013

    • Author(s)
      山口隆平、氏家弘
    • Organizer
      第36回日本バイオレオロジー学会年会抄録集
    • Place of Presentation
      九州大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Occlusion Phenomenon in Cerebral Aneurysm Model induced at Bifurcation by Stent2013

    • Author(s)
      Teruo MATSUZAWA, Hiroshi UJIIE, Ryuhei YAMAGUCHI
    • Organizer
      ESB 2013 19TH Congress of the Europian Society of Biomechanics
    • Place of Presentation
      University of Patras
    • Related Report
      2013 Research-status Report
  • [Presentation] Computational Hemodynamics Investigation of Double Aneurysms Treatment Priority2013

    • Author(s)
      Yosuke OTSUKA, Nhat Bui MINH, Hiroshi OHTAKE, Go WATANABE, Ryuhei YAMAGUCHI, Teruo MATSUZAWA
    • Organizer
      ESB 2013 19TH Congress of the Europian Society of Biomechanics
    • Place of Presentation
      University of Patras
    • Related Report
      2013 Research-status Report
  • [Presentation] 拍動流中における腎動脈分岐部の狭窄による壁せん断応力の変化2013

    • Author(s)
      山田陽平、山口隆平
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会講演論文
    • Place of Presentation
      産業技術総合研究所 つくばセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] 分岐部に生じた動脈瘤に留置したステントによる流れ構造2013

    • Author(s)
      中島駿、加藤祐樹、小泉泰己、氏家弘、山口隆平
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会講演論文
    • Place of Presentation
      産業技術総合研究所 つくばセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] 弾性壁からなる脳動脈瘤モデル内の流れの可視化2013

    • Author(s)
      小泉泰己、前川信二、加藤祐樹、氏家弘、山口隆平
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会講演論文
    • Place of Presentation
      産業技術総合研究所 つくばセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] L字型曲り部に発生した動脈瘤流れ2012

    • Author(s)
      中島駿、氏家弘、山口隆平
    • Organizer
      第35回バイオレオロジー学会年会抄録集
    • Place of Presentation
      新潟朱鷺センター
    • Related Report
      2012 Research-status Report
  • [Book] 脳神経外科2013

    • Author(s)
      山口隆平、氏家弘
    • Total Pages
      7
    • Publisher
      照林社
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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