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Understanding the Functional Expression Sequences of Proteins with a Robot Model

Research Project

Project/Area Number 24560309
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionKanagawa Institute of Technology

Principal Investigator

ARIKAWA Keisuke  神奈川工科大学, 工学部, 准教授 (50350674)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsロボット機構 / 蛋白質
Outline of Final Research Achievements

In this study, approximate protein models comprising main chain structures and linear springs were considered as robotic mechanisms. Methods were developed to effectively extract information on the functional expression of proteins from the aforementioned models. These analyses are based on responses to forces in static equilibrium. In particular, the mechanism feature analysis, which identifies mechanism features present in the shapes of proteins, is considered to be effective. Moreover, a computational platform that is capable of parallel and incremental computations was developed. Through the analyses of various types of protein systems, the study confirmed the ability to obtain insight into the understanding functional expression sequences by investigating compliance properties such as mechanism feature, in particular, observing the changes of these properties before and after the interactions with other molecules.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013 2012

All Presentation (6 results)

  • [Presentation] Analyzing Motion Properties of Proteins Affected by Localized Structures from a Robot Kinematics Perspective2015

    • Author(s)
      Keisuke Arikawa
    • Organizer
      2015 ASME, IDETC, 39th Mechanisms and Robotics Conference
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2015-08-02 – 2015-08-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] タンパク質の構造コンプライアンス解析手法の改良2014

    • Author(s)
      有川 敬輔
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Extension of the Kinematics-based Method for Predicting the Motion of Proteins2014

    • Author(s)
      Keisuke Arikawa
    • Organizer
      2014 ASME, IDETC, 38th Mechanisms and Robotics Conference
    • Place of Presentation
      Buffalo (USA)
    • Year and Date
      2014-08-17 – 2014-08-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] タンパク質の構造コンプライアンス特性の計算2013

    • Author(s)
      有川敬輔
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] A Computational Framework for Predicting the Motions of a Protein System from a Robot Kinematics Viewpoint2013

    • Author(s)
      Keisuke Arikawa
    • Organizer
      2013 ASME, IDETC, 37th Mechanisms and Robotics Conference
    • Place of Presentation
      Oregon (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] ロボット機構の運動学に基づくタンパク質の内部運動解析2012

    • Author(s)
      有川 敬輔
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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