An imaging system of human body gas for evaluation of disease screening using chemiluminescence

• Project/Area Number: 24560512
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ARAKAWA Takahiro 東京医科歯科大学, 生体材料工学研究所, 講師 (50409637)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 計測工学 / イメージング / ガス計測 / 酵素 / バイオセンサ / 生体計測 / 生体ガス / 可視化 / 化学発光 / エタノール / イメージングシステム / エタノールガス / デバイス / 流体 / 可視化計測

Outline of Final Research Achievements

An ethanol sensing and imaging system in the gas phase has been developed for analysis of breath ethanol. This breath gas imaging system has been expected to be easy, rapid and painless approach for sampling from patients to diagnose diseases. The system provides the image of ethanol distribution as chemiluminescence (CL) on the enzyme-immobilized mesh. The spatio and temporal changes in CL generated by ethanol in exhaled breath after ethanol oral administration was detected by employing an electron multiplier CCD camera. Breath samples from volunteers with aldehyde hydrogenase 2 (ALDH2) (+) and (-) are detected and analyzed with the imaging system. This imaging system for the human odor and skin gas has been expected to be the safe and useful assessment for metabolism in the body.

Research Products

• [Journal Article] Chemiluminescent imaging of transpired ethanol from the palm for evaluation of alcohol metabolism (2015)
  • Author(s): Arakawa T, Kita K, Wang X, Miyajima K, Toma K, Mitsubayashi K
  • Journal Title: Biosensors and Bioelectronics Volume: 67 Pages: 570-575
  • DOI: 10.1016/j.bios.2014.09.045
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A sniffer-camera for imaging of ethanol vaporization from wine: the effect of wine glass shape (2015)
  • Author(s): Arakawa T, Iitani K, Wang X, Kajiro T, Toma K, Yano K, Mitsubayashi K
  • Journal Title: Analyst Volume: 140 Issue: 8 Pages: 2881-2886
  • DOI: 10.1039/c4an02390k
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A direct gaseous ethanol imaging system for analysis of alcohol metabolism from exhaled breath (2013)
  • Author(s): Arakawa T, Wang X, Kajiro K, Miyajima K, Takeuchi S, Kudo H, Yano K, Mitsubayashi K
  • Journal Title: Sensors and Actuators B: Chemical Volume: Vol. 186 Pages: 27-33
  • DOI: 10.1016/j.snb.2013.05.071
  • Peer Reviewed
• [Journal Article] Chemiluminescent visualization for evaluation of gaseous ethanol distribution during 'La France' pear maturation (2013)
  • Author(s): Arakawa T, Ando E, Wang X, Miyajima K, Takeuchi S, Kudo H, Saito H, Takahashi M, Mitani T, Mitsubayashi K
  • Journal Title: IEEE Sensors Journal Volume: Vol. 13, No. 8 Issue: 8 Pages: 2842-2848
  • DOI: 10.1109/jsen.2013.2257740
  • Peer Reviewed
• [Journal Article] A highly sensitive and temporal visualization system for gaseous ethano l with chemiluminescence enhancer (2012)
  • Author(s): Arakawa I, Ando E, Wang X, Miyajima K, Kudo H, Saito H, Mitani T, Takahashi M, Mitsubayashi K
  • Journal Title: Luminescence Volume: 27 Issue: 5 Pages: 328-333
  • DOI: 10.1002/bio.1352
  • Peer Reviewed
• [Presentation] “Scent camera” for real-time imaging of breath (body) ethanol after alcohol drinking (2014)
  • Author(s): 18)Arakawa T, Sato T, Wang X, Kita K, Munkbayar M, Toma K, Mitsubayashi K
  • Organizer: DOS 2014
  • Place of Presentation: 東京
  • Year and Date: 2014-12-08 – 2014-12-09
• [Presentation] Gaseous ethanol imaging systemfrom human breath and skin for evaluation of alcohol metabolism (2014)
  • Author(s): Arakawa T, Kita K, Wang X, Miyajima K, Toma K, Mitsubayashi K
  • Organizer: International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS and Applications (Bio4Apps) 2014
  • Place of Presentation: 中国
  • Year and Date: 2014-11-17 – 2014-11-19
• [Presentation] 2-dimensional gaseous ethanol visualization system for noninvasive analysis of alcohol metabolism from exhaled human breath (2014)
  • Author(s): Arakawa T, Wang X, Miyajima K, Munkhjargal M, Mitsubayashi K
  • Organizer: IUMRS-ICA 2014
  • Place of Presentation: 福岡
  • Year and Date: 2014-08-24 – 2014-08-30
• [Presentation] Direct imaging system of gaseous ethanol from exhaled human breath for non-invasive analysis of alcohol metabolism (2014)
  • Author(s): Arakawa T, Wang X, Kajiro T, Miyajima K, Yano K, Mitsubayashi K
  • Organizer: Biosensors 2014
  • Place of Presentation: オーストラリア
  • Year and Date: 2014-07-06 – 2014-07-09
• [Presentation] Optical imaging of breath ethanol using real time biochemical luminescence for evaluation of alcohol metabolic capability (2014)
  • Author(s): Arakawa T, Wang W, Sato T, Miyajima K, Munkhjargal M, Mitsubayashi K
  • Organizer: EUROPT(R)ODE XII
  • Place of Presentation: ギリシャ
  • Year and Date: 2014-04-13 – 2014-04-16
• [Presentation] A gaseous ethanol visualization system for analysis of alcohol metabolism from exhaled breath (2013)
  • Author(s): Arakawa T, Wang X, Kita K, Miyajima K, Munkhjargal M, Mitsubayashi K
  • Organizer: 12th Asian Conference on Analytical Sciences
  • Place of Presentation: 福岡、日本
  • Invited
• [Presentation] Gaseous ethanol imaging system for real-time alcohol analysis using emission of human breath and body (2013)
  • Author(s): Arakawa T, Wang X, Kita K, Miyajima K, Munkhjargal M, Mitsubayashi K
  • Organizer: 8th International Conference on Instrumental Methods of Analysis Modern Trends and Applications
  • Place of Presentation: テッサロニキ、ギリシャ
  • Invited
• [Presentation] アルコール代謝機能評価のための呼気中エタノールガスの可視化計測システムに関する研究 (2013)
  • Author(s): 荒川貴博，王昕，神白匠，ムンフジャルガルムンフバヤル，宮島久美子，工藤寛之，矢野和義，三林浩二
  • Organizer: 電気学会センサ・マイクロマシン部門 第30回「センサ・マイクロマシンと応用システム」シンポジウム
  • Place of Presentation: 仙台、日本
  • Invited
• [Presentation] 食品由来エタノールガスの可視化センシングシステムに関する研究 (2012)
  • Author(s): 荒川貴博，王シン，安藤恵理，宮島久美子，工藤寛之，三林浩二
  • Organizer: 日本分析化学会第61年会
  • Place of Presentation: 金沢
• [Presentation] 生体触媒を利用したエタノールガスの可視化計測システムに関する研究 (2012)
  • Author(s): 齋藤幸仁，平松秀夫，王昕，宮島久美子，荒川貴博，工藤寛之，三林浩二
  • Organizer: 第24回ＳＡＳインテリジェントシンポジウム
  • Place of Presentation: 神奈川
• [Book] スマート・ヒューマンセンシング ～健康ビッグデータ時代のためのセンサ・情報・エネルギー技術～ (2014)
  • Author(s): 荒川貴博, 三林浩二 （分筆）
  • Total Pages: 8
  • Publisher: シーエムシー出版
• [Book] 医療周辺機器の開発 (2014)
  • Author(s): 荒川貴博, 三林浩二 （分筆）
  • Total Pages: 6
  • Publisher: 日本設計工学会誌
• [Book] Advances in environmental research, chapter 9 (2014)
  • Author(s): Takahiro Arakawa, Kohji Mitsubayashi
  • Total Pages: 375
  • Publisher: nova publisher
• [Remarks] 研究室ホームページ 研究概要の説明有り
  • URL: http://www.tmd.ac.jp/i-mde/www/inst/inst-j.html