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Development of a continuous-time method for intensity-modulated radiation therapy treatment planning

Research Project

Project/Area Number 24560522
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Measurement engineering
Research InstitutionThe University of Tokushima

Principal Investigator

YOSHINAGA Tetsuya  徳島大学, ヘルスバイオサイエンス研究部, 教授 (40220694)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords強度変調放射線治療 / 最適化問題 / 微分方程式 / 非線形問題
Outline of Final Research Achievements

A novel approach of using nonlinear differential equations for solving box-constrained inverse problems in intensity-modulated radiation therapy (IMRT) treatment planning was proposed, and it was investigated through theoretical analysis, numerical analysis, creation of a prototype consisting of analog electronic circuits, and numerical experiments using phantom data simulating a clinical setup. Moreover, we presented a non-negatively constrained iterative method formulated by discretizing a differential equation in the continuous method. We give proofs for the convergence of a desired solution in the continuous and its discretized system, theoretically. When the IMRT inverse problem is well-posed, the proposed methods always provide an IMRT plan that exactly satisfies preset dose limits after sufficient time passage or iteration.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (46 results)

All 2015 2014 2013 2012 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (22 results) Book (5 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Robustification of a Nonlinear Dynamical System with a Stability Index and a Matrix Inequality2015

    • Author(s)
      Oishi Yasuaki, Mio Kobayashi and Tetsuya Yoshinaga
    • Journal Title

      SICE Journal of Control, Measurement, and System Integration

      Volume: 8(3)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust bifurcation analysis based on optimization of degree of stability2015

    • Author(s)
      Hiroyuki Kitajima, Tetsuya Yoshinaga, Imura Jun-ichi and Kazuyuki Aihara
    • Journal Title

      International Journal of Innovative Computing, Information and Control

      Volume: 11(1) Pages: 153-162

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dose-volume constrained optimization in intensity-modulated radiation therapy treatment planning2015

    • Author(s)
      Yoshihiro Tanaka, Ken'ichi Fujimoto and Tetsuya Yoshinaga
    • Journal Title

      Journal of Inequalities and Applications

      Volume: 1 Issue: 1

    • DOI

      10.1186/s13660-015-0643-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A method for finding optimal parameter values using bifurcation-based procedure2014

    • Author(s)
      H. Kitajima and T. Yoshinaga
    • Journal Title

      International Journal of Modern Nonlinear Theory and Application

      Volume: 3 Issue: 02 Pages: 37-43

    • DOI

      10.4236/ijmnta.2014.32006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 拡張BVP発振器における微小周期外乱下でのMMOsの挙動2014

    • Author(s)
      伊藤 薫, 清水 邦康, 稲葉 直彦, 藤本 憲市, 吉永 哲哉, 遠藤 哲郎
    • Journal Title

      電子情報通信学会論文誌(A)

      Volume: .J97-A(1) Pages: 14-22

    • NAID

      110009688192

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bifurcation scenarios for a 3D torus and torus-doubling2014

    • Author(s)
      Naohiko Inaba, Munehisa Sekikawa, Yoshimasa Shinotsuka, Kyohei Kamiyama, Ken'ichi Fujimoto, Tetsuya Yoshinaga and Tetsuro Endo
    • Journal Title

      Progress of Theoretical and Experimental Physics

      Volume: 2014(2) Issue: 2 Pages: 1-11

    • DOI

      10.1093/ptep/ptt122

    • NAID

      120007141574

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Continuous-time method and its discretization to inverse problem of intensity-modulated radiation therapy treatment planning2014

    • Author(s)
      Ken'ichi Fujimoto, Yoshihiro Tanaka, Omar M. Abou Al-Ola and Tetsuya Yoshinaga
    • Journal Title

      Communications in Nonlinear Science and Numerical Simulation

      Volume: 19(6) Issue: 6 Pages: 1996-2004

    • DOI

      10.1016/j.cnsns.2013.10.026

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of target image regions based on bifurcations of a fixed point in a discrete-time oscillator network2013

    • Author(s)
      Ken'ichi Fujimoto, Mio Kobayashi, Tetsuya Yoshinaga and Kazuyuki Aihara
    • Journal Title

      International Journal of Innovative Computing, Information and Control

      Volume: 9(1) Pages: 355-363

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] GPU Implementation of Oscillator Network System with Plastic Coupling for Dynamic Image Segmentation2013

    • Author(s)
      Ken'ichi Fujimoto, Mio Kobayashi and Tetsuya Yoshinaga
    • Journal Title

      Journal of Electronic Systems

      Volume: 3(1) Pages: 17-24

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extended Continuous-Time Image Reconstruction System for Binary and Continuous Tomography2013

    • Author(s)
      Yusaku Yamaguchi, Ken'ichi Fujimoto and Tetsuya Yoshinaga
    • Journal Title

      Journal of Signal Processing

      Volume: 17 Issue: 4 Pages: 163-166

    • DOI

      10.2299/jsp.17.163

    • NAID

      130004849299

    • ISSN
      1342-6230, 1880-1013
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Continuous-Time Image Reconstruction for Binary Tomography2013

    • Author(s)
      Yusaku Yamaguchi, Ken'ichi Fujimoto, Omar M. Abou Al-Ola and Tetsuya Yoshinaga
    • Journal Title

      Communications in Nonlinear Science and Numerical Simulation

      Volume: 18(8) Issue: 8 Pages: 2081-2087

    • DOI

      10.1016/j.cnsns.2013.01.001

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of target image regions based on bifurcations of a fixed point in a discrete-time oscillator network2013

    • Author(s)
      Ken'ichi Fujimoto, et al.
    • Journal Title

      International Journal of Innovative Computing, Information and Control

      Volume: 9 (1) Pages: 355-363

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Convergence of Iterative Method as Discretization of Continuous-Time Image Reconstruction System for Computed Tomography2012

    • Author(s)
      Kiyoko Tateishi, Ken'ichi Fujimoto and Tetsuya Yoshinaga
    • Journal Title

      Journal of Signal Processing

      Volume: 16 Issue: 6 Pages: 617-621

    • DOI

      10.2299/jsp.16.617

    • NAID

      130004457056

    • ISSN
      1342-6230, 1880-1013
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bifurcation analyses of nonlinear dynamical systems: From theory to numerical computations2012

    • Author(s)
      Kunichika Tsumoto, et al.
    • Journal Title

      Nonlinear Theory and Its Applications, IEICE

      Volume: 3 (4) Pages: 458-476

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Convergence of Iterative Method as Discretization of Continuous-Time Image Reconstruction System for Computed Tomography2012

    • Author(s)
      Kiyoko Tateishi, et al.
    • Journal Title

      Journal of Signal Processing

      Volume: 16 (6) Pages: 617-621

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Iterative method as discretization of continuous-time method based on dose-volume constrained optimization for intensity-modulated radiation therapy treatment planning2015

    • Author(s)
      Tetsuya Yoshinaga, Yoshihiro Tanaka and Ken'ichi Fujimoto
    • Organizer
      EPOS in European Congress of Radiology 2015
    • Place of Presentation
      Austria Center Vienna (Wien, Austria)
    • Year and Date
      2015-03-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 1次元離散時間振動子の結合系にみられる振動応答を利用した動的画像領域分割2014

    • Author(s)
      小林 美緒, 吉永 哲哉
    • Organizer
      電子情報通信学会
    • Place of Presentation
      愛媛大学 (愛媛県松山市)
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非線形微分方程式を用いた磁気共鳴画像再構成2014

    • Author(s)
      山口 雄作, 藤本 憲市, 吉永 哲哉
    • Organizer
      第37回日本生体医工学会中国四国支部大会
    • Place of Presentation
      岡山大学 (岡山県岡山市)
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 微分方程式の離散化に基づくCT画像再構成法2014

    • Author(s)
      立石 貴代子, 藤本 憲市, 吉永 哲哉
    • Organizer
      第37回日本生体医工学会中国四国支部大会
    • Place of Presentation
      岡山大学 (岡山県岡山市)
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Improving image quality using an extended continuous-time CT image reconstruction system2014

    • Author(s)
      Yusaku Yamaguchi, Ken'ichi Fujimoto and Tetsuya Yoshinaga
    • Organizer
      International Journal of Computer Assisted Radiology and Surgery
    • Place of Presentation
      Fukuoka Convention Center (福岡県福岡市)
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 連続時間法による強度変調放射線治療計画の最適化2014

    • Author(s)
      田中 義浩, 藤本 憲市, 吉永 哲哉
    • Organizer
      日本放射線技術学会第70回総会学術大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2014-04-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 連続時間法を用いたDual-Energy CT画像再構成2014

    • Author(s)
      山口 雄作, 藤本 憲市, 吉永 哲哉
    • Organizer
      日本放射線技術学会第70回総会学術大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2014-04-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nonlinear continuous method for non-negatively constrained inverse problem of IMRT planning2013

    • Author(s)
      Yoshihiro Tanaka, et al.
    • Organizer
      55th AAPM Annual Meeting & Exhibition
    • Place of Presentation
      Indiana Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Nonlinear continuous method for non-negatively constrained inverse problem of IMRT planning

    • Author(s)
      Yoshihiro Tanaka, Ken'ichi Fujimoto and Tetsuya Yoshinaga
    • Organizer
      AAPM 55th Annual Meeting & Exhibition
    • Place of Presentation
      Indiana Convention Center (Indianapolis, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Controlling Method to Avoid Bifurcations of Periodic Points Using Maximum Lyapunov Exponent

    • Author(s)
      Ken'ichi Fujimoto, Tomohiro Otsu, Tetsuya Yoshinaga, Tetsushi Ueta, Hiroyuki Kitajima and Kazuyuki Aihara
    • Organizer
      2013 International Symposium on Nonlinear Theory and its Applications
    • Place of Presentation
      El Dorado Hotel and Spa (Santa Fe, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] A coupling model of photon propagation based on the radiative transfer and diffusion equations

    • Author(s)
      Fujii Hiroyuki, Hoshi Yoko, Okawa Shinpei, Tetsuya Yoshinaga, Kohno Satoru and Yamada Yukio
    • Organizer
      11th International Conference of Numerical Analysis and Applied Mathematics
    • Place of Presentation
      Rodos Palace Hotel (Rhodes, Greece)
    • Related Report
      2013 Research-status Report
  • [Presentation] Successive Algorithm Using Discrete-Time Oscillator Network for Three-Dimensional Image Segmentation

    • Author(s)
      Ken'ichi Fujimoto, Mio Kobayashi and Tetsuya Yoshinaga
    • Organizer
      International Conference on Innovations in Engineering and Technology
    • Place of Presentation
      First hotel Bangkok (Bangkok, Thailand)
    • Related Report
      2013 Research-status Report
  • [Presentation] Image errors of timeresolved optical tomography based on the radiative transfer and diffusion equations

    • Author(s)
      Fujii Hiroyuki, Okawa Shinpei, Tetsuya Yoshinaga, Yamada Yukio, Hoshi Yoko and Kohno Satoru
    • Organizer
      9th International Conference on Optics-photonics Design & Fabrication
    • Place of Presentation
      Itabashi Culture Center (Tokyo, Japan)
    • Related Report
      2013 Research-status Report
  • [Presentation] Magnetic resonance image reconstruction using nonlinear continuous-time dynamical system

    • Author(s)
      Yusaku Yamaguchi, Ken'ichi Fujimoto and Tetsuya Yoshinaga
    • Organizer
      2014 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Place of Presentation
      Waikiki Beach Marriott Resort & Spa (Honolulu, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Continuous-time method based on dose optimization for intensity-modulated radiation therapy treatment planning

    • Author(s)
      Tetsuya Yoshinaga, Yoshihiro Tanaka, and Ken'ichi Fujimoto
    • Organizer
      EPOS in European Congress of Radiology 2014
    • Place of Presentation
      Austria Center Vienna (Wien, Austria)
    • Related Report
      2013 Research-status Report
  • [Presentation] 連続法の離散化反復法による強度変調放射線治療計画

    • Author(s)
      田中 義浩, et al.
    • Organizer
      第104回日本医学物理学会学術大会
    • Place of Presentation
      つくば国際会議場 (茨城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 拡張連続法を用いた強度変調放射線治療計画

    • Author(s)
      橋戸 宏輔, et al.
    • Organizer
      第104回日本医学物理学会学術大会
    • Place of Presentation
      つくば国際会議場 (茨城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 強度変調放射線治療計画のためのスイッチト連続法

    • Author(s)
      橋戸 宏輔, et al.
    • Organizer
      第8回 中四国放射線医療技術フォーラム2012
    • Place of Presentation
      松山市総合コミュニティセンター (愛媛県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 強度変調放射線治療計画のための離散化連続法

    • Author(s)
      田中 義浩, et al.
    • Organizer
      日本放射線技術学会近畿部会 第56回学術大会
    • Place of Presentation
      大阪国際会議場 (大阪府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Extended Continuous-Time Image Reconstruction System for Binary and Continuous Tomography

    • Author(s)
      Yusaku Yamaguchi, et al.
    • Organizer
      2013 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Place of Presentation
      Courtyard King Kamehameha's Kona Beach Hotel (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Electronic Circuit Design of a Block Continuous-Time Image Reconstruction System

    • Author(s)
      Yoshiaki Akaishi, et al.
    • Organizer
      2013 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
    • Place of Presentation
      Courtyard King Kamehameha's Kona Beach Hotel (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Continuous-Time Method to Inverse Problem of Intensity-Modulated Radiation Therapy Treatment Planning

    • Author(s)
      Ken'ichi Fujimoto, et al.
    • Organizer
      European Congress of Radiology 2013
    • Place of Presentation
      Austria Center Vienna (Austria)
    • Related Report
      2012 Research-status Report
  • [Book] Robust Bifurcation Analysis Based on Degree of Stability2015

    • Author(s)
      Hiroyuki Kitajima, Tetsuya Yoshinaga, Jun-ichi Imura, Kazuyuki Aihara
    • Total Pages
      211
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Use of a Matrix Inequality Technique for Avoiding Undesirable Bifurcation2015

    • Author(s)
      Yasuaki Oishi, Mio Kobayashi, Tetsuya Yoshinaga
    • Total Pages
      211
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] A Method for Constructing a Robust System Against Unexpected Parameter Variation2015

    • Author(s)
      Hiroyuki Kitajima, Tetsuya Yoshinaga
    • Total Pages
      211
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Parametric Control to Avoid Bifurcation Based on Maximum Local Lyapunov Exponent2015

    • Author(s)
      Ken’ichi Fujimoto, Tetsuya Yoshinaga, Tetsushi Ueta, Kazuyuki Aihara
    • Total Pages
      211
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Continuous-Time Image Reconstruction for Computed Tomography in Computed Tomography: New Research2013

    • Author(s)
      Ken'ichi Fujimoto, et al.
    • Total Pages
      512
    • Publisher
      Nova Science Publishers
    • Related Report
      2012 Research-status Report
  • [Remarks] 医用画像機器工学分野

    • URL

      http://www.tokushima-u.ac.jp/med/culture/iyo_gazokiki/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 医用画像機器工学分野

    • URL

      http://www.tokushima-u.ac.jp/med/culture/iyo_gazokiki/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 医用画像機器工学分野

    • URL

      http://www.tokushima-u.ac.jp/med/culture/iyo_gazokiki/index.html

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 強度変調放射線治療計画装置,強度変調放射線照射装置の放射線ビーム係数演算方法,強度変調放射線治療計画プログラム及びコンピュータで読み取り可能な記録媒体並びに記録した機器2012

    • Inventor(s)
      吉永 哲哉, 藤本 憲市
    • Industrial Property Rights Holder
      吉永 哲哉, 藤本 憲市
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-07-27
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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