Production of calcium phosphate on titanium from a simulated body fluid flowing in a confined space

• Project/Area Number: 24560821
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Inorganic materials/Physical properties
• Research Institution: Niigata University
• Principal Investigator: KIMURA ISAO 新潟大学, 自然科学系, 教授 (00169921)
• Co-Investigator(Kenkyū-buntansha): TAGUCHI Yoshinari 新潟大学, 自然科学系, 准教授 (30293202)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: リン酸カルシウム / チタン / 疑似体液 / 流動 / 化学工学

Outline of Final Research Achievements

A small reactor involving a confined space was fabricated, in which calcium phosphate (CaP) was produced on titanium by flowing a simulated body fluid (SBF). The mixing characteristics in the reactor were evaluated by the impulse response testing. The relationship between the intermittently flowing conditions of SBF and the CaP yield was discussed. The crystalline phase of the product was identified as calcium-deficient hydroxyapatite. It was found that dispersion intensity is useful as an evaluation index of mixing characteristics instead of dispersion number used in general. The production of CaP was accelerated at larger dispersion intensity more than static condition. The knowledge on the effects of the SBF composition was also obtained.

Research Products

• [Presentation] リン酸カルシウム系化合物の生成に及ぼす疑似体液の間欠流通間隔および流速の影響 (2014)
  • Author(s): 佐藤裕昭, 田口佳成, 木村勇雄
  • Organizer: 化学工学会新潟大会
  • Place of Presentation: 新潟大学（新潟県）
  • Year and Date: 2014-11-22
• [Presentation] チタン上でのリン酸カルシウム生成に及ぼす水溶液組成の影響 (2014)
  • Author(s): 鈴木浩正, 木村勇雄
  • Organizer: 化学工学会新潟大会
  • Place of Presentation: 新潟大学（新潟県）
  • Year and Date: 2014-11-22
• [Presentation] 回転反応器中におけるチタン上でのリン酸カルシウム化合物の生成 (2014)
  • Author(s): 岡村 駿, 木村勇雄
  • Organizer: 化学工学会新潟大会
  • Place of Presentation: 新潟大学（新潟県）
  • Year and Date: 2014-11-22
• [Presentation] Dissolution behavior of hydroxyapatite microspheres in HBSS (2014)
  • Author(s): Zhang Zhongying, Isao Kimura
  • Organizer: 化学工学会新潟大会
  • Place of Presentation: 新潟大学（新潟県）
  • Year and Date: 2014-11-22
• [Presentation] リン酸カルシウム系化合物の生成に及ぼす疑似体液の流動乱れの影響 (2014)
  • Author(s): 佐藤裕昭, 田口佳成, 木村勇雄
  • Organizer: 日本セラミックス協会東北北海道支部研究発表会
  • Place of Presentation: 秋田市にぎわい交流館AU（秋田県）
  • Year and Date: 2014-11-06
• [Presentation] Solubility of hydroxyapatite microspheres synthesized in a W/O/W emulsion (2014)
  • Author(s): Zhang Zhongying, Isao Kimura
  • Organizer: 日本化学会北海道支部2014年夏季研究発表会
  • Place of Presentation: 苫小牧高専（北海道）
  • Year and Date: 2014-07-12
• [Presentation] Deposition of calcium phosphate on titanium in a confined space
  • Author(s): Isao Kimura, Hiroaki Sato, Yoshinari Taguchi
  • Organizer: Collaborative Conference on 3D & Materials Research 2013
  • Place of Presentation: Jeju（韓国）
  • Invited
• [Presentation] 制限空間内でのリン酸カルシウム系化合物の生成に及ぼす混合特性の影響
  • Author(s): 佐藤裕昭, 田口佳成, 木村勇雄
  • Organizer: 化学工学会第45回秋季大会
  • Place of Presentation: 岡山大学（岡山県）
• [Presentation] 疑似体液からの化合物生成装置の作製と混合特性評価
  • Author(s): 佐藤裕昭, 田口佳成, 木村勇雄
  • Organizer: 化学工学会第78年会
  • Place of Presentation: 大阪大学（大阪府）
• [Presentation] 制限空間内でのヒドロキシアパタイトの生成に及ぼす疑似体液間欠流通の影響
  • Author(s): 佐藤裕昭, 田口佳成, 木村勇雄
  • Organizer: 日本セラミックス協会2013年年会
  • Place of Presentation: 東京工業大学（東京都）