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Development of new aortic stent-graft materials by plasma technology that can control the surface morphology and the drug elution

Research Project

Project/Area Number 24560860
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural/Functional materials
Research InstitutionTokai University

Principal Investigator

HASEBE Terumitsu  東海大学, 医学部, 教授 (20306799)

Co-Investigator(Kenkyū-buntansha) SUZUKI Tetsuya  慶應義塾大学, 理工学部, 教授 (10286635)
Co-Investigator(Renkei-kenkyūsha) HOTTA Atsushi  慶應義塾大学, 理工学部, 教授 (30407142)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords新機能材料 / 非晶質炭素膜 / リン脂質ポリマー / マイクロパターニング / 薬剤徐放 / プラズマ技術 / 細胞接着制御 / ステントグラフト内 / エンドリーク / 炭素系薄膜 / プラズマ / 薬剤徐放部材 / 血管内皮細胞 / 線維芽細胞
Outline of Final Research Achievements

Endovascular aneurysm repair (EVAR) using a stent-graft is designed to help prevent an aneurysm from bursting. Endoleaks are characterized by persistent blood flow within the aneurysm sac following EVAR. In this study, to inhibit the endoleak inflow, we controlled the surface morphology and the drug elution of graft material by plasma technology, and we developed new materials for a graft fabric that enhanced cell adhesion and proliferation. As the specific results, we revealed that (1) the control of the surface morphology and the drug emission contributed to the proliferation of endothelial cells and that (2) micro-patterned hydrogenated amorphous carbon (a-C:H) coating on the polymer impregnated with basic fibroblast glows factor (bFGF) improved the endothelial cells growth rate.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (30 results)

All 2015 2014 2013 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (18 results) (of which Invited: 5 results) Book (1 results)

  • [Journal Article] Balloon-occluded transarterial chemoembolization using a 1.8-French tip Coaxial microballoon catheter for hepatocellular carcinoma: Technical and safety considerations.2015

    • Author(s)
      Matsumoto T*, Endo J, Hashida K, Ichikawa H, Kojima S, Takashimizu S, Watanabe N, Yamagami T, Hasebe T* (* Matsumoto T and Hasebe T equally contributed to this work.)
    • Journal Title

      Minim Invasive Ther Allied Technol

      Volume: 24 Pages: 94-100

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and characterization of 2-methacryloyloxyethyl phosphorylcholine polymer nanofibers prepared via electrospinning for biomedical materials2014

    • Author(s)
      Maeda, T., Hagiwara, K., Yoshida, S., Hasebe, T. & Hotta, A.
    • Journal Title

      Journal of Applied Polymer Science

      Volume: 131 Issue: 14 Pages: 40606-40606

    • DOI

      10.1002/app.40606

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of combined use of imprint cytological and histological examination in CT-guided tissue-core biopsy.2014

    • Author(s)
      Yamagami T, Yoshimatsu R, Kajiwara K, Ishikawa M, Matsumoto T, Kakizawa H, Toyoda N, Hasebe T, Awai K
    • Journal Title

      Eur Radiol

      Volume: 24 Pages: 1127-1134

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic Fibroblast Growth Factor as a Potential Stent Coating Material Inducing Endothelial Cell Proliferation2014

    • Author(s)
      Kitamura, N., Hasebe, T., Matsumoto, T, Hotta, A., Suzuki, T., Yamagami, T. & Terada, H.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 21 Issue: 5 Pages: 477-485

    • DOI

      10.5551/jat.20404

    • NAID

      130004444732

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surface modification of polymers by plasma treatments for the enhancement of biocompatibility and controlled drug release2013

    • Author(s)
      Yoshida, S., Hagiwara, K., Hasebe, T. & Hotta, A.
    • Journal Title

      Surface and Coating Technology

      Volume: - Pages: 99-107

    • DOI

      10.1016/j.surfcoat.2013.02.042

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrophobicity and non-thrombogenicity of nanoscale dual rough surface coated with fluorine-incorporated diamond-like carbon films: Biomimetic surface for blood-contacting medical devices2013

    • Author(s)
      Hasebe, T., Nagashima, S., Kamijo, A., Moon, M.W., Kashiwagi, Y., Hotta, A., Lee, K.R., Takahashi, K., Yamagami, T. & Suzuki, T.
    • Journal Title

      Diamond and Related Materials

      Volume: 38 Pages: 14-18

    • DOI

      10.1016/j.diamond.2013.06.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural characterization of surface-induced platelet activation on artificial materials by transmission electron microscopy2013

    • Author(s)
      Yoshimoto, Y., Hasebe, T., Takahashi, K., Amari, M., Nagashima, S., Kamijo, A., Hotta, A., Takahashi, K. & Suzuki, T.
    • Journal Title

      Microscopy Research and Technique

      Volume: Vol.76,Issue4 Issue: 4 Pages: 342-349

    • DOI

      10.1002/jemt.22172

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of plasma treatments on the controlled drug release from poly(ethylene-co-vinyl acetate)2013

    • Author(s)
      Hagiwara, K., Hasebe, T. & Hotta, A.
    • Journal Title

      Surface and Coatings Technology

      Volume: Vol.216 Pages: 318-323

    • DOI

      10.1016/j.surfcoat.2012.11.064

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Controlled formation of wrinkled diamond-like carbon (DLC) film on grooved poly(dimethylsiloxane) substrate.2012

    • Author(s)
      Hasebe T*, Nagashima S*, Tsuya D, Horikoshi T, Ochiai M, Tanigawa S, Koide Y, Hotta A, Suzuki T. (* Hasebe T and Nagashima S equally contributed to this work.)
    • Journal Title

      Diam Relat Mater

      Volume: 22 Pages: 48-51

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human umbilical vein endothelial cell interaction with fluorine-incorporated amorphous carbon films2012

    • Author(s)
      Yoshimoto, Y., Hasebe, T., Nagashima, S., Kamijo A., Nakatani, T., Yamagami T., Kitamura, N. & Kitagawa T.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: Vol.51 Issue: 9R Pages: 1-7

    • DOI

      10.1143/jjap.51.090129

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tailoring surface topographies of polymers by using ion beam : Recent advances and the potential applications in biomedical and tissue engineering2011

    • Author(s)
      T.Hasebe, S.Nagashima, Y.Yoshimoto, A.Hotta, T.Suzuki
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B : Beam Interactions with Materials and Atoms

      Volume: (In press) Pages: 134-136

    • DOI

      10.1016/j.nimb.2011.08.066

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 炭素系材料が開く新世代医療器具の開発2015

    • Author(s)
      長谷部光泉, 松本知博, 中村挙子, 大花 継頼 , 堀田篤, 鈴木哲也
    • Organizer
      ナノカーボンバイオシンポジウム
    • Place of Presentation
      東京大学伊藤国際学術研究センター, 日本
    • Year and Date
      2015-02-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 医工産学連携による血管内治療デバイスの開発の取り組み-From bench to bedside-2015

    • Author(s)
      長谷部光泉, 松本知博
    • Organizer
      第33回群馬IVR研究会
    • Place of Presentation
      群馬大学医学部臨床中講堂, 日本
    • Year and Date
      2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炭素系材料が開く新世代医療器具の開発2014

    • Author(s)
      長谷部光泉, 松本知博, 堀田 篤, 鈴木哲也
    • Organizer
      第28回ダイヤモンドシンポジウム
    • Place of Presentation
      東京電機大学, 日本
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 医工連携プロジェクトによる国内型血管内ステントの開発2014

    • Author(s)
      長谷部光泉, 松本知博, 堀田篤, 鈴木哲也
    • Organizer
      第17回日本栓子検出と治療学会
    • Place of Presentation
      福岡大学病院福大メディカルホール, 日本
    • Year and Date
      2014-10-04 – 2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hydrogen-free amorphous carbon film: Antibacterial and antithrom bogenic biocompatible coating. International Conference on Diamond and Carbon Materials (Young Scholar Award受賞)2014

    • Author(s)
      Kanazawa H, Hasebe T, Kitagawa T, Matsumoto T, Suzuki T
    • Organizer
      International Conference on Diamond and Carbon Materials 2014
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2014-09-06 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 冠動脈ステントへのDLC コーティングについて―優れた生体適合性コーティング―2014

    • Author(s)
      長谷部光泉, 松本知博
    • Organizer
      第23回日本血管インターベンション治療学会学術集会
    • Place of Presentation
      名古屋国際会議場, 日本
    • Year and Date
      2014-07-24 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 早期内皮化促進性および抗血栓性を有するbFGF溶出性冠動脈ステントシステムの開発(最優秀賞受賞)2014

    • Author(s)
      尾藤健太, 長谷部光泉, 堀田篤
    • Organizer
      第37回日本バイオレオロジー学会年会
    • Place of Presentation
      大宮ソニックシティビル, 日本
    • Year and Date
      2014-06-05 – 2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Newly developed drug-eluting stent system: Non-thrombogenic 2-methacryloyloxyethyl phosphorylcholine polymer combined with micro-patterned diamond-like carbon film as a scaffold for complete endothelial cells proliferation.2013

    • Author(s)
      Kitagawa N, Hasebe T, Kitamura N, Nagashima S, Suzuki T
    • Organizer
      International Conference on Diamond and Carbon Materials 2013
    • Place of Presentation
      Riva Del Garda-Fiere congressi Spa, Riva Del Garda, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] Newly developed drug-eluting stent (DES) system for cardiovascular diseases.2013

    • Author(s)
      Hasebe T, Kitagawa T, Nagashima S, Matsumoto T, Kitamura N, Hotta A, Suzuki T
    • Organizer
      International Symposium on Atomic Level Characterizations for New Materials and Devices (ALC) 2013
    • Place of Presentation
      Sheraton Kona, The Big Island, Hawaii, USA
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 医工連携プロジェクトによるIVRリサーチ:基礎研究から臨床研究へ2013

    • Author(s)
      長谷部光泉
    • Organizer
      栃木県放射線医会
    • Place of Presentation
      那須赤十字病院,日本
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 細胞接着性制御可能なマイクロパターニングDLC-MPCポリマー複合材料:薬剤徐放性血管内留置デバイスへの応用可能性(最優秀賞受賞)2013

    • Author(s)
      前川駿人,長谷部光泉,北川智也,鈴木哲也
    • Organizer
      第27回ダイヤモンドシンポジウム
    • Place of Presentation
      日本工業大学学友館,日本
    • Related Report
      2013 Research-status Report
  • [Presentation] Controlling the drug release rate from electrospun phospholipid polymer nanofibers with micro-patterned diamond-like carbon (DLC) coating.2013

    • Author(s)
      Yoshida S, Hasebe T, Suzuki T, Hotta A.
    • Organizer
      APS March Meeting 2013
    • Place of Presentation
      Baltimore Convention Center, Baltimore, MD, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Human umbilical vein endothelial cell interaction with phospholipid polymer nanofibers coated by micro-patterned diamond-like carbon (DLC).2013

    • Author(s)
      Yoshida S, Hasebe T, Suzuki T, Hotta A.
    • Organizer
      APS March Meeting 2013.
    • Place of Presentation
      Baltimore Convention Center, Baltimore, MD, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体適合性に優れた国産DLCコーティングステントとその臨床成績2012

    • Author(s)
      長谷部光泉
    • Organizer
      第21回 日本心血管インターベンション治療学会・学術集会
    • Place of Presentation
      朱雀メッセ,新潟市,日本
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 医工連携プロジェクトによる次世代生体適合性血管内デバイスの開発2012

    • Author(s)
      長谷部光泉
    • Organizer
      第53回真空に関する連合講演会
    • Place of Presentation
      甲南大学ポートアイランドキャンパス,神戸市,日本
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Controlling the drug release rate from biocompatible polymers by changing plasma-treated area.2012

    • Author(s)
      Hagiwara K, Hasebe T, Asakawa R, Kamijo A, Suzuki T, Hotta A.
    • Organizer
      39th ICMCTF (International Conference on Metallurgical Coatings and Thin Films)
    • Place of Presentation
      Town & Country Convention Center, San Diego, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of argon plasma treatment on controlling the drug release rate from biocompatible polymers.2012

    • Author(s)
      Hagiwara K, Hasebe T, Suzuki T, Hotta A.
    • Organizer
      39th ICMCTF (International Conference on Metallurgical Coatings and Thin Films)
    • Place of Presentation
      Town & Country Convention Center, San Diego, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Anti-bacterial property of Hydrogen-free amorphous carbon coatings on Ar plasma-pretreated polytetrafluoroethylene (PTFE) with a-C:H:F interlayer.2012

    • Author(s)
      Umemoto H, Hasebe T, Kasai R, Yoshimoto Y, Nagashima S, Hotta A, Suzuki T.
    • Organizer
      2012 MRS Fall Meeting & Exhibit
    • Place of Presentation
      The Hynes Convention Center, Boston, MA, USA
    • Related Report
      2012 Research-status Report
  • [Book] Diamond-Like Carbon Coated on Polymers for Biomedical Applications. Thin Films and Coatings in Biology, Biological medical physics, Biomedical Engineering Series. Nazarpour S (Ed.)2013

    • Author(s)
      Hotta A, Hasebe T (invited contrib)
    • Total Pages
      58
    • Publisher
      Springer, USA
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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