| Project/Area Number |
24560860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural/Functional materials
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Tetsuya 慶應義塾大学, 理工学部, 教授 (10286635)
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| Co-Investigator(Renkei-kenkyūsha) |
HOTTA Atsushi 慶應義塾大学, 理工学部, 教授 (30407142)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 新機能材料 / 非晶質炭素膜 / リン脂質ポリマー / マイクロパターニング / 薬剤徐放 / プラズマ技術 / 細胞接着制御 / ステントグラフト内 / エンドリーク / 炭素系薄膜 / プラズマ / 薬剤徐放部材 / 血管内皮細胞 / 線維芽細胞 |
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| Outline of Final Research Achievements |
Endovascular aneurysm repair (EVAR) using a stent-graft is designed to help prevent an aneurysm from bursting. Endoleaks are characterized by persistent blood flow within the aneurysm sac following EVAR. In this study, to inhibit the endoleak inflow, we controlled the surface morphology and the drug elution of graft material by plasma technology, and we developed new materials for a graft fabric that enhanced cell adhesion and proliferation. As the specific results, we revealed that (1) the control of the surface morphology and the drug emission contributed to the proliferation of endothelial cells and that (2) micro-patterned hydrogenated amorphous carbon (a-C:H) coating on the polymer impregnated with basic fibroblast glows factor (bFGF) improved the endothelial cells growth rate.
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