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Foundamental research for microparticle formation by rapid expansion of supercritical solution method

Research Project

Project/Area Number 24560921
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionKanazawa University

Principal Investigator

HIGASHI Hidenori  金沢大学, 自然システム学系, 助教 (40294889)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords微粒子 / 超臨界二酸化炭素 / 薬用成分 / 粒度分布 / 結晶 / 形態変化 / 拡散律速モデル / 表面反応律速モデル / 急速膨張法 / ナノ粒子 / 溶解度 / 超臨界流体 / ケトプロフェン / 微粒子化 / レーザーアブレーション / 炭素 / 平均粒径 / モデリング
Outline of Final Research Achievements

The purpose of this work is clarify the influence of the concentration of solute in supercritical carbon dioxide on the forms of the generated fine particles of medicinal component via rapid expansion of supercritical solution.
Submicron fine particles and crystalline coarse particles were observed at high concentration region. Only submicron fine particles were observed at lower concentration of solute. The forms of generated particles were observed and the size distribution was determined by the SEM image.
The two particle formation mechanism, surface reaction control and diffusion control models, were considered to represent the formation of submicron fine particles and crystalline coarse particles. The mean particle sizes were well represented by the two models.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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