Control of the internal and surface structures of biodegradable porous membranes with the aid of surfactants and their application to bioprocess

• Project/Area Number: 24560957
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Niigata University
• Principal Investigator: TANAKA Takaaki 新潟大学, 自然科学系, 教授 (00217043)
• Co-Investigator(Renkei-kenkyūsha): KAWASE Tomoyuki 新潟大学, 医歯学系, 准教授 (90191999)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 多孔質膜 / 生分解性材料 / 生体材料 / バイオプロセス / バイオセパレーション / 国際情報交換 / アメリカ合衆国

Outline of Final Research Achievements

Biodegradable separation membrane and scaffold materials have been developed by controlling their internal and surface structures with the aid of surfactants. Asymmetric microporous separation membranes of poly(L-lactic acid) with pores in the order of 0.1 μm were prepared from the polymer solutions containing surfactants with the hydrophilic-lipophilic balance (HLB) values from 15.3 to 16.7. Osteoblast-like cells grew in the 500 μm-thick biodegradable microporous membranes when the cells were seeded on the rough side of the membranes.

Research Products

• [Journal Article] 生分解性ポリエステル多孔質膜に支持された培養細胞シート (2016)
  • Author(s): 民部裕洋，田中孝明
  • Journal Title: 膜 Volume: 40 Pages: 124-129
  • NAID: 130005075555
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Preparation of poly(L-lactic acid) microfiltration membranes by nonsolvent-induced phase separation method with the aid of surfactants. (2015)
  • Author(s): Minbu H, Ochiaki A, Kawase T, Taniguchi M, LLoyd DR, Tanaka T.
  • Journal Title: J Membr Sci Volume: 479 Pages: 85-94
  • DOI: 10.1016/j.memsci.2015.01.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 膜を利用した固液系深層濾過 (2014)
  • Author(s): 田中孝明
  • Journal Title: 膜 Volume: 39 Pages: 21-27
  • NAID: 130004780919
  • Peer Reviewed
• [Journal Article] Microporous membranes of PLLA/PCL blends for periosteal tissue scaffold. (2013)
  • Author(s): Kouya l Tada S, Minbu H, Nakajima Y, Horimizu M, Kawase T, Lloyd DR, Tanaka T
  • Journal Title: Mater Lett Volume: 95 Pages: 103-106
  • DOI: 10.1016/j.matlet.2012.12.076
  • Peer Reviewed
• [Presentation] 界面活性剤を用いて作製したポリ乳酸膜の濾過特性 (2015)
  • Author(s): 水野陽樹，民部裕洋，谷口正之，田中孝明
  • Organizer: 化学工学会第47回秋季大会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2015-09-11
• [Presentation] 多孔質膜を利用した固液系深層濾過 (2015)
  • Author(s): 田中孝明
  • Organizer: 化学工学会第47回秋季大会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2015-09-10
  • Invited
• [Presentation] バイオ分離用シングルユースデプスフィルター (2015)
  • Author(s): 田中孝明
  • Organizer: 化学工学会第47回秋季大会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2015-09-10
  • Invited
• [Presentation] Development of microfiltration membranes of biomass and biodegradable plastics (2015)
  • Author(s): H. Minbu, A. Ochiai, M. Taniguchi, T. Tanaka
  • Organizer: GSC-7 & 4th JACI/GSC Symposium
  • Place of Presentation: 一橋講堂（東京都千代田区）
  • Year and Date: 2015-07-07
  • Int'l Joint Research
• [Presentation] 界面活性剤を用いて作製したポリ乳酸製多孔質膜の骨芽細胞用細胞培養への応用 (2014)
  • Author(s): 民部裕洋，谷口正之，川瀬知之，田中孝明
  • Organizer: 化学工学会新潟大会2014
  • Place of Presentation: 新潟大学（新潟市）
  • Year and Date: 2014-11-22
• [Presentation] Protein adsorption and recovery by hydroxyapatite microcapsules and their composite membranes with microporous membranes (2014)
  • Author(s): T. Tanaka Y. Takai, A. Nagase, K. Teraguchi, S. Tada, Hi. Minbu, I.
  • Organizer: The 10th International Congress on Membranes and Membrane Processes
  • Place of Presentation: Taihu International Conference Center (Suzuhou, China)
  • Year and Date: 2014-07-24
• [Presentation] PLLA microporous membranes prepared via nonsolvent induced phase separation method with surfactants (2014)
  • Author(s): H. Minbu, M. Taniguchi, D.R. Lloyd, T. Tanaka
  • Organizer: The 10th International Congress on Membranes and Membrane Processes
  • Place of Presentation: Taihu International Conference Center (Suzuhou, China)
  • Year and Date: 2014-07-22
• [Presentation] 界面活性剤を用いたポリ乳酸製多孔質膜の作製と評価 (2014)
  • Author(s): 民部裕洋，谷口正之，田中孝明
  • Organizer: 日本膜学会年会
  • Place of Presentation: 早稲田大学（東京都新宿区）
  • Year and Date: 2014-05-12
• [Presentation] Control of Microstructure of PLLA Membranes with Nonionic Surfactants (2013)
  • Author(s): T. Tanaka, H. Minbu, M. Taniguchi, D. Lloyd
  • Organizer: 9th World Congress of Chemical Engineering
  • Place of Presentation: Coex, Seoul, Korea
• [Presentation] 非溶媒誘起相分離法を用いたポリ乳酸製濾過膜の作製と評価 (2013)
  • Author(s): 民部裕洋，谷口正之，田中孝明
  • Organizer: 化学工学会第45回秋季大会
  • Place of Presentation: 岡山大学（岡山市）
• [Presentation] Microporous membranes of biodegradable polyesters for biomedical applications (2013)
  • Author(s): 田中孝明
  • Organizer: 化学工学会第78年会
  • Place of Presentation: 大阪大学
  • Invited
• [Presentation] 界面活性剤を用いたポリ乳酸製濾過膜の開発 (2012)
  • Author(s): 民部裕洋，谷口正之，田中孝明
  • Organizer: 化学工学会第44回秋季大会
  • Place of Presentation: 東北大学
• [Book] 多孔質フィルム／膜の製造技術 (2016)
  • Author(s): 田中孝明，佐光貞樹，川島敏行，富康博，石塚紀生，瀧健太郎，串﨑義幸，平井悠司，下村政嗣，横山英明，早川晃鏡，武野明義，高橋紳矢，松田裕行，小野寺恒信，笠井均，及川英俊，河野公一，山田一博，西川聡
  • Total Pages: 150
  • Publisher: S&T出版
• [Book] 濾過スケールアップの正しい進め方と成功事例集 (2014)
  • Author(s): 山下明泰，田中孝明，浦瀬太郎，伊藤雅喜，高島由布子，大村岳雄，入谷英司，中村一穂，青木裕，山村寛，深澤宏，志村靖二，中倉英雄，田中孝徳，岩田政司，橋本光紀，横井誠，加藤智，向井康人，熊野淳夫，他７１名
  • Total Pages: 531
  • Publisher: 技術情報協会
• [Remarks] 「生分解性プラスチックを機能材料へ」
  • URL: http://tctanaka.eng.niigata-u.ac.jp/FunctionalBiodegradablePlastics_a5.pdf
• [Remarks] 「生分解性プラスチックを機能材料へ」
  • URL: http://tctanaka.eng.niigata-u.ac.jp/FunctionalBiodegradablePlastics_a5.pdf
• [Remarks] 生分解性プラスチックを機能材料へ
  • URL: http://tctanaka.eng.niigata-u.ac.jp/FunctionalBiodegradablePlastics_a5.pdf