| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Design and synthesis of fluorescent probes for the detection of aldehyde-modified proteins were carried out based on the knowledge obtained by the development of fluorescent reagents for the detection of proteins. As a result, molecular probes for the detection of aldehyde-modified proteins constructed by binding site and fluorescent molecules were developed, and fluorescence enhancement was observed after reaction between fluorescent probes and aldehyde-modified proteins. Moreover, fluorescent gel images after electrophoresis enabled the monitoring of aldehyde-modified proteins.
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