Analysis of regulatory mechanisms for the DNA damage tolerance pathway
| Project/Area Number |
24570010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Gakushuin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HISHIDA Takashi 学習院大学, 理学部, 教授 (60335388)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | DNA損傷トレランス / DNA相同組換え / ゲノム動態 |
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| Outline of Final Research Achievements |
Genomic DNA is constantly damaged by exposure to endogenous metabolic products and exogenous DNA-damaging agents. DNA replication stress caused by DNA damages potentially leads to genomic mutations and genome instabilities. On the other hand, replication stress can be abolished through the DNA-damage tolerance pathway. In this study, we analyzed a regulatory mechanism of DNA damage tolerance. Our findings indicate that dynamics of chromatin and novel factors are important for regulation of the DNA damage tolerance pathway.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] A Replicase Clamp-Binding Dynamin-like Protein Promotes Colocalization of Nascent DNA Strands and Equipartitioning of Chromosomes in E. coli.2013
Author(s)
Ozaki, S., Matsuda, Y., Keyamura, K., Kawakami, H., Noguchi, Y., Kasho, K., Nagata, K., Masuda, T., Sakiyama, Y., Katayama, T.
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Journal Title
Cell Reports
Volume: 4
Issue: 5
Pages: 985-995
DOI
Related Report
Peer Reviewed
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[Journal Article] The DnaA N-terminal domain interacts with Hda to facilitate replicase clamp-mediated inactivation of DnaA2013
Author(s)
Su'etsugu, M., Harada, Y., Keyamura, K., Matsunaga, C., Kasho, K., Abe, Y., Ueda, T. and Katayama, T.
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Journal Title
nviron. Microbiol.
Volume: (印刷中)
Issue: 12
Pages: 3183-3195
DOI
Related Report
Peer Reviewed
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