| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Genomic DNA is constantly damaged by exposure to endogenous metabolic products and exogenous DNA-damaging agents. DNA replication stress caused by DNA damages potentially leads to genomic mutations and genome instabilities. On the other hand, replication stress can be abolished through the DNA-damage tolerance pathway. In this study, we analyzed a regulatory mechanism of DNA damage tolerance. Our findings indicate that dynamics of chromatin and novel factors are important for regulation of the DNA damage tolerance pathway.
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