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Identification of neural circuitry controlling the courtship song of Drosophila

Research Project

Project/Area Number 24570082
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionTohoku University

Principal Investigator

KOGANEZAWA Masayuki  東北大学, 生命科学研究科, 准教授 (10302085)

Co-Investigator(Renkei-kenkyūsha) YAMAMOTO Daisuke  東北大学, 大学院生命科学研究科, 教授 (50318812)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsショウジョウバエ / 求愛行動 / fruitless / doublesex
Outline of Final Research Achievements

The sexual differentiation of somatic cells in Drosophila is controlled by the terminal genes in the sex determination hierarchy; fruitless (fru) and doublesex (dsx). Recent studies revealed that neurons expressing these genes play central role in the courtship behavior. The courtship song produced by a male fly is one of the hallmarks of courtship of Drosophila. To reveal the neural basis for courtship song production, I performed behavioral experiments by using the technique to manipulate neural activity of fru/dsx-expressing neurons. In this study, I identified 4 types of dsx-expressing neurons controlling proper courtship song production.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (32 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (25 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] The Drosophila Lingerer protein cooperates with Orb2 in long-term memory formation.2014

    • Author(s)
      Kimura, S., Sakakibara, Y., Sato, K., Ote, M., Ito, H., Koganezawa, M., and Yamamoto, D.
    • Journal Title

      J. Neurogenet.

      Volume: 29 Issue: 1 Pages: 8-17

    • DOI

      10.3109/01677063.2014.917644

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neuroethology of male courtship in Drosophila: from the gene to behavior.2014

    • Author(s)
      Yamamoto D., Sato K., and Koganezawa M.
    • Journal Title

      J. Comp. Physiol. A.

      Volume: 200 Issue: 4 Pages: 251-264

    • DOI

      10.1007/s00359-014-0891-5

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Select interneuron clusters determine female sexual receptivity in Drosophila2013

    • Author(s)
      Sakurai, A., Koganezawa, M., Yasunaga, K., Emoto, K. and Yamamoto, D.
    • Journal Title

      Nat. Commun.

      Volume: 4 Pages: 1825-1833

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genes and circuits of courtship behavior in Drosophila males.2013

    • Author(s)
      Yamamoto, D. and Koganezawa, M.
    • Journal Title

      Nat. Rev. Neurosci.

      Volume: 14 Issue: 10 Pages: 681-692

    • DOI

      10.1038/nrn3567

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism.2012

    • Author(s)
      Ito, H., Sato, K., Koganezawa, M., Ote, M., Matsumoto, K., Hama, C., Yamamoto, D.
    • Journal Title

      Cell

      Volume: 149 Issue: 6 Pages: 1327-1338

    • DOI

      10.1016/j.cell.2012.04.025

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Pheromone sensitive interneurons switching courtship and aggression in Drosophila.2014

    • Author(s)
      Koganezawa, M., and Yamamoto, D.
    • Organizer
      The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists
    • Place of Presentation
      The Miyagi-Zao Royal Hotel and Tohoku University
    • Year and Date
      2014-12-07 – 2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sex-specific functions of longitudinals lacking.2014

    • Author(s)
      Sato, K., Toba, G., Ito, H., Koganezawa, M., Binglong, Z., and Yamamoto, D.
    • Organizer
      The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists
    • Place of Presentation
      The Miyagi-Zao Royal Hotel and Tohoku University
    • Year and Date
      2014-12-07 – 2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional characterization of the calcium channel in Drosophila embryonic muscles.2014

    • Author(s)
      Hara, Y., Koganezawa, M., and Yamamoto, D.
    • Organizer
      The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists
    • Place of Presentation
      The Miyagi-Zao Royal Hotel and Tohoku University
    • Year and Date
      2014-12-07 – 2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neuropeptide-expressing neurons regulate sexual receptivity in Drosophila females.2014

    • Author(s)
      Miwa, Y., Koganezawa, M., Emoto, K. and Yamamoto, D.
    • Organizer
      The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists
    • Place of Presentation
      The Miyagi-Zao Royal Hotel and Tohoku University
    • Year and Date
      2014-12-07 – 2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Searching for neurons that regulate female sexual receptivity in Drosophila.2014

    • Author(s)
      Miwa, Y., Koganezawa, M., Emoto, K., and Yamamoto, D.
    • Organizer
      The 37th Annual Meeting of the Molecular Biology society of Japan
    • Place of Presentation
      Kanagawa
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ショウジョウバエ脳神経系の雄化因子Fruitlessがもつ転写調節以外の機能2014

    • Author(s)
      佐藤耕世, 鳥羽岳太, 伊藤弘樹, 小金澤雅之, 山元大輔
    • Organizer
      第6回新学術領域研究「性差構築の分子基盤」領域会議
    • Place of Presentation
      舘山寺サゴーロイヤルホテル
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] ショウジョウバエ脳神経系の雄化因子Fruitless がもつ転写調節以外の機能2014

    • Author(s)
      佐藤耕世,鳥羽岳太,伊藤弘樹,小金澤雅之,山元大輔
    • Organizer
      日本動物学会第85回仙台大会
    • Place of Presentation
      東北大学川内キャンパス
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] doublesex-expressing neurons controlling female reproductive behavior in Drosophila.2014

    • Author(s)
      Kimura, K., Sato, C., Koganezawa, M., and Yamamoto D.
    • Organizer
      11th International Congress of Neuroethology (ICN)
    • Place of Presentation
      Sapporo
    • Year and Date
      2014-07-28 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neural circuitry switching between courtship and aggression in Drosophila.2014

    • Author(s)
      Koganezawa, M., and Yamamoto, D.
    • Organizer
      11th International Congress of Neuroethology (ICN)
    • Place of Presentation
      Sapporo
    • Year and Date
      2014-07-28 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] ショウジョウバエの求愛/攻撃の切り替えに関わるfruitless発現神経回路2014

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      平成26年度日本動物学会東北支部大会
    • Place of Presentation
      岩手大学復興祈念銀河ホール
    • Year and Date
      2014-07-12 – 2014-07-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sex-specific functions of longitudinals lacking2013

    • Author(s)
      Sato, K., Toba, G., Ito, H., Koganezawa, M. and Yamamoto, D.
    • Organizer
      Neurobiology of Drosophila, Cold Spring Harbor Laboratory
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] ショウジョウバエの求愛/攻撃を制御する脳内fruitless発現ニューロン2013

    • Author(s)
      小金澤雅之,山元大輔
    • Organizer
      日本動物学会 第84回年会
    • Place of Presentation
      岡山大学津島キャンパス,岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 強制活性化法を用いた求愛と攻撃を制御する中枢ニューロンの同定2013

    • Author(s)
      小金澤雅之,山元大輔
    • Organizer
      平成25年度日本動物学会 東北支部大会
    • Place of Presentation
      秋田大学手形キャンパス・大学会館クレール,秋田
    • Related Report
      2013 Research-status Report
  • [Presentation] ショウジョウバエの求愛と攻撃を制御するフェロモン感受性介在ニューロンの同定2013

    • Author(s)
      小金澤雅之,山元大輔
    • Organizer
      日本味と匂学会 第47回大会
    • Place of Presentation
      仙台市民会会館,宮城
    • Related Report
      2013 Research-status Report
  • [Presentation] 雌キイロショウジョウバエの産卵管突き出し行動に関与するdsx発現ニューロン2013

    • Author(s)
      佐藤千晶,小金澤雅之,山元大輔,木村賢一
    • Organizer
      日本動物学会 第84回年会
    • Place of Presentation
      岡山大学津島キャンパス,岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] ショウジョウバエにおける“種特異的”求愛行動パターンを生み出す神経基盤2013

    • Author(s)
      小金澤雅之
    • Organizer
      第6回Evo-devo青年の会「新奇性の生まれるとき The Emergence of Evoltionary Novelities」
    • Place of Presentation
      東京大学三崎臨海実験所、神奈川
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Functional dissection of fru/dsx-expressing neural circuitry generating Drosophila courtship behavior2012

    • Author(s)
      Koganezawa, M., Yamamoto, D.
    • Organizer
      The 34th Annual Meeting of the Japanese Society of Comparative Physiology and Biochemistry
    • Place of Presentation
      Shonan Village Center, Kanagawa
    • Related Report
      2012 Research-status Report
  • [Presentation] ショウジョウバエ種特異的求愛行動パターンを生み出すfru発現神経回路2012

    • Author(s)
      小金澤雅之、山元大輔
    • Organizer
      平成24年度日本動物学会東北支部大会
    • Place of Presentation
      山形大学理学部、山形
    • Related Report
      2012 Research-status Report
  • [Presentation] ショウジョウバエdoublesex発現ニューロン群における性差-1.性差形成機構2012

    • Author(s)
      木村賢一、佐藤千晶、小金澤雅之、山元大輔
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学、豊中
    • Related Report
      2012 Research-status Report
  • [Presentation] ショウジョウバエdoublesex発現ニューロン群における性差-2.雌生殖行動の制御2012

    • Author(s)
      佐藤千晶、小金澤雅之、山元大輔、木村賢一
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学、豊中
    • Related Report
      2012 Research-status Report
  • [Presentation] ショウジョウバエ求愛歌を制御するfruitless/doublesex発現神経回路2012

    • Author(s)
      小金澤雅之、山元大輔
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学、豊中
    • Related Report
      2012 Research-status Report
  • [Presentation] Functional dissection of neural circuitry generating Drosophila courtship song by intersectional approach2012

    • Author(s)
      Koganezawa, M., Yamamoto, D.
    • Organizer
      The 35th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya Congress Center, Nagoya
    • Related Report
      2012 Research-status Report
  • [Presentation] ショウジョウバエ求愛行動を司るfruitless発現神経回路2012

    • Author(s)
      小金澤雅之
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      九州大学医学部、福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Electrophysiological properties of Drosophila embryonic body-wall muscles and their synaptic regulation2012

    • Author(s)
      Yokoyama, S., Yoshihara, M., Koganezawa, M., Yamamoto, D.
    • Organizer
      Japanese Drosophila Research Conference 2012
    • Place of Presentation
      Jikei University School of Medicine, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Indetification of neurons controlling female reproductive behavior in Drosophila2012

    • Author(s)
      Sato, C., Koganezawa, M., Yamamoto, D., Kimura, K.-I.
    • Organizer
      Japanese Drosophila Research Conference 2012
    • Place of Presentation
      Jikei University School of Medicine, Tokyo
    • Related Report
      2012 Research-status Report
  • [Book] Insect pheromone behavior: fruit fly. Methods. Mol. Biol. 1068, 261-272. In: Pheromone Signaling, Ed. K. Tohara2013

    • Author(s)
      Yamamoto, D., Kohatsu, S. and Koganezawa, M.
    • Total Pages
      399
    • Publisher
      Humana Press, Springer
    • Related Report
      2013 Research-status Report
  • [Book] in vivo optical recording of brain interneuron activities from a Drosophila male on a treadmill. In: Genetically Encoded Functional Indicators, J.-R. Martin Ed.2012

    • Author(s)
      Kohatsu, S., Koganezawa, M., Yamamoto, D.
    • Publisher
      Humana Press Springer: New York
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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