Molecular basis of nitric oxide action underlying the insect olfactory associative learning
| Project/Area Number |
24570083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokyo Gakugei University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | キノコ体 / ケニオン細胞 / イオンチャネル / 一酸化窒素 / ｃGMP / 嗅覚連合学習 / フタホシコオロギ / 連合学習 / Patch clamp / Ion channel / Mushroom body / Kenyon cell / Brain / Olfactory learning / Insect / Patch clamp / Associative learning |
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| Outline of Final Research Achievements |
Crickets have high capacity to form olfactory long-term memory. Previous studies have pointed to the importance of the nitric oxide (NO) signaling cascade in the formation of olfactory long-term memory within mushroom bodies. However,the mechanisms by which NO modulates neuronal excitability in mushroom bodies and results in the formation of LTM are not well understood. In the present study, we have revealed that NO increases the frequency and number of action potentials in Kenyon cells via modulation of various kinds of ionic channels including persisten Na, L-type Ca, Na-activated K, and BK channels.We conclude that NO acts as a modulator resulting in a stimulatory signal in Kenyon cells.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Ionic channel mechanisms mediating the intrinsic excitability of Kenyon cells in the mushroom body of the cricket brain.2014
Author(s)
Shigeki Inoue, Kaoru Murata, Aiko Tanaka, Eri Kakuta, Saori Tanemura, Shiori Hatakeyama, Atunao Nakamura, Chihiro Yamamoto, Masaharu Hasebe, Kumiko Kosakai, Masami Yoshino
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Journal Title
Journal of Insect Physiology
Volume: 68
Pages: 44-57
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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