| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
Crickets have high capacity to form olfactory long-term memory. Previous studies have pointed to the importance of the nitric oxide (NO) signaling cascade in the formation of olfactory long-term memory within mushroom bodies. However,the mechanisms by which NO modulates neuronal excitability in mushroom bodies and results in the formation of LTM are not well understood. In the present study, we have revealed that NO increases the frequency and number of action potentials in Kenyon cells via modulation of various kinds of ionic channels including persisten Na, L-type Ca, Na-activated K, and BK channels.We conclude that NO acts as a modulator resulting in a stimulatory signal in Kenyon cells.
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