Analysis on molecular environments that bring cell-specific photoresponses to rod and cone photoreceptors.
| Project/Area Number |
24570085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 視細胞 / 錐体 / 桿体 / 光応答 / 動物生理化学 |
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| Outline of Final Research Achievements |
In vertebrate retina, there are two kinds of photoreceptor cells, called cones and rods. Cones and rods mediate daylight vision and night vision, respectively. Corresponding to each function, cones and rods show different characteristics in photoresponses. In this study, the molecular bases of the differences on photoresponses were investigated using isolated cones and rods from carp (Cyprinus carpio) retina. It was found that the lipid composition in cell membranes of outer segments, the region of photoreceptor cells generating photoresponses, are different between cones and rods. The proteomic analyses on the expressed proteins in outer segment membranes showed the presence of unknown cone- and rod-specific proteins. In addition, it was found that the efficiencies of some enzymatic reactions working to generate photoresponses are different between rods and cones. These differences are thought to contribute the differences in photoresponses between cones and rods.
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Report
(5 results)
Research Products
(29 results)
