| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Outline of Final Research Achievements |
The aim of this research is to understand the molecular mechanisms involved in homologous recombination in the context of the chromatin structure. Homologous recombination is initiated by a double-strand break, and is followed by the search for homologous DNA sequences in the genome. The genomic DNA, however, is composed of nucleosomes, which compacts the DNA. This compaction is a potential barrier for homologous recombination. Through structural studies of the interactions between proteins involved in promoting homologous recombination and nucleosomes, we have identified interactions between recombination proteins and nucleosomes that may provide important insights into the mechanism of DNA homology search that takes place on the chromatin.
|
